DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and W01B6.5

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_501826.2	Gene:	W01B6.5 / 189082	WormBaseID:	WBGene00012172	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	517	Identity:	135/517 - (26%)
Similarity:	236/517 - (45%)	Gaps:	92/517 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   860 KEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHP------FESSSGELDENSDRDIDN 918
            ||.....|.|....|:.....|:   |:.|:.: ...|:.|      .|:|..:|..|   |:..
Worm    19 KEEHTVVPRGKEEKEKKPGTKPS---PISPAFK-GTPKERPNCGKTKNETSGKKLRSN---DVSP 76

  Fly   919 DEEEEDSASDDVLSMKDH---CYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDF 980
            |.:       |.|.:.:|   ..|:..........|..|.     |||.:.||:::.:|.|.|||
Worm    77 DVK-------DRLQLSEHGPSKTCIKDFQWLEDFITKMPC-----FHGFIGREDLMSVLKNVGDF 129

  Fly   981 LVRETI--------RNEESQIVLSVCWN-----------------------GHKHFIVQTTGEGN 1014
            |:|.::        :.:::|..:.|..|                       |.:.|::....:..
Worm   130 LIRTSVQPNKHEVEKMKKNQADVKVLGNLSREKCAKKEKEKEEKLAGMGDVGRREFVISVYCKDK 194

  Fly  1015 FR--FEGPPFASIQELIMHQ----------------------YHSELPVTVKSGAILRRPVCRER 1055
            .:  .:.|.:..|:.|::.:                      |.....:..::...|..|:....
Worm   195 EKPATDKPQYTPIRNLVIKRDNGMVHVEPLRKFKTLTEFFGYYQKNSGICKETDFQLITPIPLSN 259

  Fly  1056 WELSNDDVVLLE-RIGRGNFGDVY--KAKLKSTK--LDVAVKTCR--MTLPDEQKRKFLQEGRIL 1113
            ||..::|:.|.: ::|.|.||:|.  |.||||||  ::||||..|  ..:..||..:.|.|.|::
Worm   260 WEFIHEDIALQQKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVM 324

  Fly  1114 KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLES 1178
            :..||.|:::..||.|.|:|:.::.|:...|:|..|||:|...:|..:::.....::.|::||.|
Worm   325 RMMDHKNVLRSYGIAVLKEPLYLMTEMCACGALREYLRENQETVTLAEKLFFVVGSSRGVQYLHS 389

  Fly  1179 KNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDV 1243
            :..||||||.||.|:..:.:.||||||:::..|.|.:.:..| |||::.|||.|....:|:..||
Worm   390 QKTIHRDLAVRNILLSEDRTPKISDFGLAKISERYEMKEQCK-IPVRYLAPETLESFIFTTKTDV 453

  Fly  1244 WSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQ-CWAADAESR 1304
            :|:|.::|||:..|:.|:.|......|........:....|.|.|:.:|:.: .:.:|.|:|
Worm   454 FSFGCVIWEIYENGNQPHDGKNAQTIRNLTKKNQFLKLTNSAPSELRKLIEERVFTSDPENR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	22/140 (16%)
		TyrKc	1063..1311	CDD:197581	87/250 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	86/246 (35%)
W01B6.5	NP_501826.2	SH2	104..241	CDD:301589	23/141 (16%)
		PTKc	272..524	CDD:270623	86/245 (35%)
		TyrKc	272..524	CDD:197581	86/245 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810