DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and T25B9.5

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001293881.1	Gene:	T25B9.5 / 188883	WormBaseID:	WBGene00012011	Length:	546	Species:	Caenorhabditis elegans

Alignment Length:	445	Identity:	131/445 - (29%)
Similarity:	205/445 - (46%)	Gaps:	75/445 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   911 NSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAAS-ISLSTNRPLYEEEW----------FHGV 964
            ::..||:..::..:.|..|.|...:     .:::.| :|.|::.|  ||::          :|||
Worm    23 DASSDIEASDKNPNEAGADKLESGN-----KNVSTSMMSNSSSDP--EEDYIRSHLINLHVYHGV 80

  Fly   965 LPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEG------NFRFEGPP- 1021
            |...|..:||..|..:|||..|......:.:||.|... .|:.:....:|      ..:|...|
Worm    81 LFGSEAEKLLTWDRAYLVRRAITKPNKFLCISVNWKKKIFHYQLDFNEDGWCCKKLYEKFPTMPN 145

  Fly  1022 --FASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKS 1084
              |..|::| :..:....|..:        |..|....|.:..:.|.:::|.|.||:|:|.:.|:
Worm   146 RRFLHIRQL-LEAWPQATPFLI--------PTPRGSNVLIHSTINLDKKLGCGAFGEVFKGQYKA 201

  Fly  1085 T-----KLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGG 1144
            .     .::||||........:|.::|..|.:|:....|.|||...|....::|||:|||||.||
Worm   202 VGSTNPPIEVAVKRILGNAKRKQIQEFCNEAQIMTVLQHENIVAFYGFASLEEPIMVVMELVTGG 266

  Fly  1145 SLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE 1209
            .|..||:...| :...|.:....:.|:|||:|.||..||||||||||||..:...||||||:|.:
Worm   267 DLRKYLQTTQN-IPKLQILWFAMNVASGMRHLSSKGIIHRDLAARNCLVTQDLKAKISDFGLSLQ 330

  Fly  1210 EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERID 1274
            ..| :.:..:::.|::|.|||:|..|.:....||||||:.:.|:.              ||...|
Worm   331 GTE-VTTKNLEKAPIRWLAPESLKSGMFNEKTDVWSYGVFLTELM--------------ARCEHD 380

  Fly  1275 TGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF------DEIYNVVDALILRLDN 1323
            ..|    |||..:      .:.|.. .|.|||.      .|:..::||...|..|
Worm   381 PLY----PKSLKD------AKAWIL-TEERPHKMENGDPKELMVLIDACCERNPN 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/105 (24%)
		TyrKc	1063..1311	CDD:197581	90/258 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	89/258 (34%)
T25B9.5	NP_001293881.1	SH2	77..158	CDD:214585	22/81 (27%)
		STYKc	180..436	CDD:214568	94/272 (35%)
		PTKc	184..437	CDD:270623	93/268 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.870