DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and kin-5

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_501793.1	Gene:	kin-5 / 188489	WormBaseID:	WBGene00002193	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	130/358 - (36%)
Similarity:	208/358 - (58%)	Gaps:	15/358 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 LYEEEWFHGVLPREEVVRLLNNDGDFLVRETIR--NEESQIVLSV---CWNGHKHFIVQTTGEGN 1014
            |.:|.|:||:||||::.:||...||||||.|..  .|..:.||||   .....:|::::   |.|
Worm    11 LAKEPWYHGLLPREDMKQLLTQRGDFLVRFTDPKVGEPRKFVLSVYVGVIEDIRHYVIR---EHN 72

  Fly  1015 FRF--EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDV 1077
            .:|  :...|:||.:|:.:.:.|:.||......::.||:.||.||..:.||.|::::|.|.||:|
Worm    73 NKFAVDKKWFSSIADLLNYYHRSKEPVAGGPETVIIRPIGREPWEKQHSDVTLIKKLGEGAFGEV 137

  Fly  1078 YKAKLK--STKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVME 1139
            ...:::  :|....|:|..:: :|..||.::.:.|.|:::::.|||:|...|:...::|:|::||
Worm   138 QLGEIRIGNTVKKAAIKLAKLESLTKEQIKEIMHEARLMRKFKHPNVVTFYGVAAGQEPLMVIME 202

  Fly  1140 LVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDF 1204
            |...|:|.:||:||...|...::..|...|..|:.||.|...||||:|:||||.. ...||||||
Worm   203 LADNGALDSYLKKNIGSLPISKKHTMVLQAGLGLEYLHSLQIIHRDIASRNCLYG-NGQVKISDF 266

  Fly  1205 GMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRA 1269
            |:|||...|.::. .|::|::|.|||....|.||...||::||::.||::..|..||.||..:..
Worm   267 GLSREGYSYRMNP-HKKVPIRWLAPEVPRTGFYTPKTDVFAYGVMCWEVYHDGIEPYPGMKVAEV 330

  Fly  1270 RERIDTGYRMPTPKSTPEEMYRLMLQCWAADAE 1302
            ..|:..|||||...:.|..:.|.:.....|.||
Worm   331 LPRVQNGYRMPFEANVPPAIVRFITYRICAGAE 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	32/90 (36%)
		TyrKc	1063..1311	CDD:197581	89/243 (37%)
		PTKc_Fes_like	1067..1315	CDD:270637	87/239 (36%)
kin-5	NP_501793.1	SH2_Fps_family	11..99	CDD:198224	32/90 (36%)
		TyrKc	123..376	CDD:197581	89/243 (37%)
		PTKc	127..376	CDD:270623	87/239 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810