Protein Alignment FER and Pik3r3

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_006502922.1
• Gene: Pik3r3 / 18710
• MGIID: 109277
• Length: 487
• Species: Mus musculus
• Alignment Length: 514
• Identity: 104/514 - (20%)
• Similarity: 171/514 - (33%)
• Gaps: 164/514 - (31%)

  Fly   863 EVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSAS 927
            |::.||          .||...||:.|:| .:|.|
Mouse    31 EMDPPA----------LPPKPPKPMTPAV-TNGMK------------------------------ 54

  Fly   928 DDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEE 990
            |..:|::|                      .||:.|.:.||||...|.:  ||.||||:.....:
Mouse    55 DSFISLQD----------------------AEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQ 97

  Fly   991 SQIVLSVCWNGHKHFIVQTTGEGNFRFEGP-PFASIQELIMHQYHSEL-PVTVKSGAILRRPVCR 1053
            ....|::...|:...|.....:|.:.|..| .|.|:.|||.|.:|..| ....|....|..||.|
Mouse    98 GDYTLTLRKGGNNKLIKIYHRDGKYGFSEPLTFTSVVELINHYHHESLAQYNPKLDVKLTYPVSR 162

  Fly  1054 -ERWELSNDDVVLLERIGRG--NFGDVYKAKLKS----------TKLDVAVKTCRMTLPDEQKRK 1105
             ::.:|..:|.:  :.:|:.  .|...|:.|.|.          |..::.:|...:...:|..:.
Mouse   163 FQQDQLVKEDNI--DAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKI 225

  Fly  1106 FLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDA- 1169
            |.::....:|:....|.:......:|:...|:|              |.:.|.:|  :|...|:
Mouse   226 FEEQCHTQEQHSKDYIERFRREGNEKEIERIMM--------------NYDKLKSR--LGEIHDSK 274

  Fly  1170 ----------AAGMRYLESK-NCIHRDLAARNCLVDLEHSVKISDFGMSR-------------EE 1210
                      |...|.::.| |.|..||.....:.| :|.|.::..|:.:             .:
Mouse   275 LRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRD-QHLVWLNHRGVRQRRLNAWLGIKNEDSD 338

  Fly  1211 EEYIVSDGMKQIP-----------VKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGM 1264
            |.|.:::..:.:|           :.....|.|.:||...       ..|:.|...||....|.:
Mouse   339 ESYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDG-------AFLIRESSKKGCYACSVV 396

  Fly  1265 TNSRARERIDTGYRM-----------------PTPKSTPEEMYRL-----MLQCWAADA 1301
            ..|.|...:..|.|:                 |.|...|....||     .|.|...||
Mouse   397 RGSEALCHLQHGSRIWLCRTLQPVQLTEGAGAPLPADIPGSAQRLPQRQARLPCPCTDA 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/89 (31%)
		TyrKc	1063..1311	CDD:197581	55/309 (18%)
		PTKc_Fes_like	1067..1315	CDD:270637	55/305 (18%)
Pik3r3	XP_006502922.1	SH2_nSH2_p85_like	59..167	CDD:198195	35/129 (27%)
		iSH2_PI3K_IA_R	172..332	CDD:355389	31/178 (17%)
		SH2	351..>396	CDD:387587	10/51 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910