DRSC/TRiP Functional Genomics Resources

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Protein Alignment FER and Pik3r1

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_001070963.1 Gene:Pik3r1 / 18708 MGIID:97583 Length:724 Species:Mus musculus


Alignment Length:759 Identity:152/759 - (20%)
Similarity:245/759 - (32%) Gaps:251/759 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   418 NGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQ 482
            ||||  :........||              |.:...||  ||.|   |.||..|         .
Mouse    57 NGYN--ETTGERGDFPG--------------TYVEYIGR--KRIS---PPTPKPR---------P 91

  Fly   483 PRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRL------RR 541
            ||...:          .|..::.|..|.   :||..:..|.|:.|.....||.|.:|      :.
Mouse    92 PRPLPV----------APGSSKTEADTE---QQALPLPDLAEQFAPPDVAPPLLIKLLEAIEKKG 143

  Fly   542 TQCSMLCLGEDEEPVVLASPAPLTQL----TAAVLTNTNNNHIYADL------------------ 584
            .:||.|...:..     ::||.|.||    .|:|.....:.|:.||.                  
Mouse   144 LECSTLYRTQSS-----SNPAELRQLLDCDAASVDLEMIDVHVLADAFKRYLADLPNPVIPVAVY 203

  Fly   585 -ELDKKKDTSPSPECKGEQIQPKKEQIRI-------------------EINQTAPQNSIDAHLDR 629
             |:........|||   :.||..|:.||:                   :::|.:.:|.::|.:  
Mouse   204 NEMMSLAQELQSPE---DCIQLLKKLIRLPNIPHQCWLTLQYLLKHFFKLSQASSKNLLNARV-- 263

  Fly   630 IDELNRVLDDRLKRTLQPSDD-----VNAIE---SAEENHIQ-TRKLAKDPDSQTKRSSSSSSEC 685
               |:.:....|.|....|.|     :.|||   |.|.|..| ...|...|...|..:::|.:..
Mouse   264 ---LSEIFSPVLFRFPAASSDNTEHLIKAIEILISTEWNERQPAPALPPKPPKPTTVANNSMNNN 325

  Fly   686 RS-----------SKDTSHSKKRSLS--------FSQKSISNIFSNLKEFSKSPLVRM----GK- 726
            .|           |::..:.|.|..:        .|.|...:....|::...:.|:::    || 
Mouse   326 MSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKY 390

  Fly   727 ---------------NHILNE-------EQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKN 769
                           ||..||       :.|.|...|...:.........|..:.....:..|..
Mouse   391 GFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQ 455

  Fly   770 TSSNSNH---------SASQSTIITSTITTTITTT---------TTTTPSKENSRLKFKVPKIQK 816
            ....|..         ..||...:..|.......|         |....|||... |||....:|
Mouse   456 FQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIE-KFKREGNEK 519

  Fly   817 KSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEF-EVEQPAGSAADEQFCNCP 880
            :.:.|.:       |....:|:..:....|||:  .:.:...|.|: |:::...|          
Mouse   520 EIQRIMH-------NHDKLKSRISEIIDSRRRL--EEDLKKQAAEYREIDKRMNS---------- 565

  Fly   881 PAGQKPVKPS-VQISGHKDHPF---------ESSSGEL--DENSDRDIDNDEEEEDSASDDVLSM 933
                  :||. :|:...:|...         :....|.  :||::......|::||....|    
Mouse   566 ------IKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHD---- 620

  Fly   934 KDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL--NNDGDFLVRETIRNEESQIVLS 996
                                   |:.|..|...|.:...||  ..||.|||||:  :::.....|
Mouse   621 -----------------------EKTWNVGSSNRNKAENLLRGKRDGTFLVRES--SKQGCYACS 660

  Fly   997 VCWNGH-KHFIVQTTGEGNFRFEGP--PFASIQELIMHQYHSEL 1037
            |..:|. ||.::..|..| :.|..|  .::|::||::|..|:.|
Mouse   661 VVVDGEVKHCVINKTATG-YGFAEPYNLYSSLKELVLHYQHTSL 703

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 28/90 (31%)
TyrKc 1063..1311 CDD:197581
PTKc_Fes_like 1067..1315 CDD:270637
Pik3r1NP_001070963.1 SH3_PI3K_p85alpha 5..79 CDD:212843 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 80..109 11/50 (22%)
RhoGAP_p85 115..302 CDD:239853 43/199 (22%)
SH2_nSH2_p85_like 328..435 CDD:198195 16/106 (15%)
PI3K_P85_iSH2 439..598 CDD:293063 30/184 (16%)
iSH2_PIK3R1 440..600 CDD:214017 30/185 (16%)
SH2_cSH2_p85_like 617..720 CDD:198184 29/117 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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