DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Ddr2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_036018652.1	Gene:	Ddr2 / 18214	MGIID:	1345277	Length:	864	Species:	Mus musculus

Alignment Length:	462	Identity:	125/462 - (27%)
Similarity:	199/462 - (43%)	Gaps:	114/462 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   900 PFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGV 964
            |.|||.    .|::|.....|:|.:|..|.:..:                   ||.|:|.
Mouse   458 PSESSM----FNNNRSSSPSEQESNSTYDRIFPL-------------------RPDYQEP----- 494

  Fly   965 LPREEVVRLLNNDGDFLVRETIRNEE---SQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQ 1026
                  .||:....:|...|    ||   |.:|.....||.               ||.|
Mouse   495 ------SRLIRKLPEFAPGE----EESGCSGVVKPAQPNGP---------------EGVP----- 529

  Fly  1027 ELIMHQYHSELPVTVKSGAILRRPVCRERWE---LSNDDVVL----------LERIGRGNFGDVY 1078
                  :::|..:....|.......|.....   ||..||.:          .|::|.|.||:|:
Mouse   530 ------HYAEADIVNLQGVTGGNTYCVPAVTMDLLSGKDVAVEEFPRKLLAFKEKLGEGQFGEVH 588

  Fly  1079 --------KAKLKSTKLD--------VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGI 1127
                    |.|.|...||        ||||..|.......:..||:|.:|:.:...|||::|:.:
Mouse   589 LCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAV 653

  Fly  1128 CVQKQPIMIVMELVLGGSLLTYLRK-------NSNGLTTRQQMG-MCRDAAAGMRYLESKNCIHR 1184
            |:.:.|:.::.|.:..|.|..:|.:       :|:...:...:. |....|:||:||.|.|.:||
Mouse   654 CITEDPLCMITEYMENGDLNQFLSRHEPLSSCSSDATVSYANLKFMATQIASGMKYLSSLNFVHR 718

  Fly  1185 DLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYG 1247
            |||.|||||...:::||:||||||.  ..:|....|...:|::|.:.|::..||:|:..|||::|
Mouse   719 DLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFG 783

  Fly  1248 ILMWEIFS-KGDTPYSGMTNSRARERIDTGYR-------MPTPKSTPEEMYRLMLQCWAADAESR 1304
            :.:||.|: ..:.|||.:::.:..|.....:|       :|.|...|:.:|:|||.||..:.:.|
Mouse   784 VTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHR 848

  Fly  1305 PHFDEIY 1311
            |.|.||:
Mouse   849 PSFQEIH 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/88 (20%)
		TyrKc	1063..1311	CDD:197581	91/291 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	91/279 (33%)
Ddr2	XP_036018652.1	FA58C	42..194	CDD:238014
Ddr2	XP_036018652.1	PKc_like	567..860	CDD:419665	91/289 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910