DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and F09A5.2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001360730.1	Gene:	F09A5.2 / 181440	WormBaseID:	WBGene00008599	Length:	867	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	175/754 - (23%)
Similarity:	291/754 - (38%)	Gaps:	203/754 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   671 PDSQTKRSSSSSSECRSSKDTSHSK------KRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHI 729
            |.:..:.:.:.|..|.:...:|:.|      ...|.:|...:||..|.|:..:|:.|...||:.|
Worm   112 PKNLKQYTGNISDACLAGIKSSNCKTWLMTNAVILKYSDDVVSNCPSILEFVNKTSLSCSGKSQI 176

  Fly   730 --LNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTI 792
              :..:.|           |:.|||    :.|...|:|.......|.|:|           .|.|
Worm   177 QYMYPQSD-----------SASSDC----NHSYDFNSNALNRAIYNFNYS-----------KTLI 215

  Fly   793 TTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFD 857
            :|:...||.       |.:           .||..|::|           |..:..|.....:.:
Worm   216 STSYANTPG-------FAM-----------YTFLLKIMN-----------CVNKNGIKLDAGILN 251

  Fly   858 ---------------FAKEFE------VEQPAGSAADEQFCN----------------CPPAGQK 885
                           |...|.      :|  ||......|.|                |.....:
Worm   252 IFTDMTYIDLCESDVFMSSFPDTLNKLIE--AGYIVKFYFLNQNLQDTQKNVENVLAGCKYMNSR 314

  Fly   886 PVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEED---SASDDVLSMKDHCY-----CVPS 942
            .....|..|.|.::|.|.      |....|.....::||   ..::.:|.:...|.     |:..
Worm   315 SYCEIVDWSYHSENPNEF------EICIPDSQPSGKKEDFNWHVTELLLIIGIPCISLTICCIAF 373

  Fly   943 L-----AASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGH 1002
            .     .|.:.::..|                 :.:.:||       |.:|.: ::.|...|.|.
Worm   374 FVCCLKCAKLKMAMMR-----------------MNVFSND-------THQNPD-EMELKKRWIGM 413

  Fly  1003 KHFIVQTTGEGNFRFEGPPFASIQELIMHQY-HSELPVTVKSGAILRRPVCRERWELSNDDVVLL 1066
            :....:....|          |.:||...:: |............|.....::.||:...::::.
Worm   414 RKKFNKDVENG----------SCKELNTQKWSHFASANNYMDIQALANANKKDIWEIDTKNLLVQ 468

  Fly  1067 E--RIGRGNFGDVYKAKLKSTKLDVAV--KTCRMT---------------LP---DEQKR-KFLQ 1108
            |  .:|.|.|.:|||..:|. |:.:.|  .:..||               ||   |||.. .|..
Worm   469 EDHLLGNGAFANVYKGIVKG-KIPLLVVNNSLNMTVESENNGHYEAAIKKLPAHADEQNHLDFFH 532

  Fly  1109 EGRILKQY-DHPNIVKLIGICVQK--QPIMIVMELVLGGSLLTYLRKNSNGLTTRQ------QMG 1164
            |...:|:. .||:::.::| ||..  :| :||:|....|.||.:||::.:.:...:      :..
Worm   533 EIDFMKRLGHHPHVISMLG-CVSNPYEP-LIVVEYCARGDLLKFLRRHKDYVLMNKTDDCPIEAD 595

  Fly  1165 MC---RD-------AAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGM 1219
            ||   :|       .|.||.||.|||.|||||||||.|:....:.|:||||:.|..:..:.:...
Worm   596 MCLRIKDLVSIAWQVADGMSYLASKNFIHRDLAARNILLTKSLTAKVSDFGLCRYMDSALYTAKG 660

  Fly  1220 KQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKS 1284
            .::|:||.:.|||...::::..||||:|:|::||||.||.||..:......|.:..|.|:..|..
Worm   661 GRLPIKWMSVEALKLYEFSTKTDVWSFGVLLFEIFSMGDVPYPTIQQVDMLEHLLAGGRLSQPLK 725

  Fly  1285 TPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            .|.|::.:|.:|||...|.||.|:|:...: .::|.||:
Worm   726 CPNEIFNIMQKCWAEKPEDRPEFNEMRGEI-TVMLNLDD 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	13/86 (15%)
		TyrKc	1063..1311	CDD:197581	96/289 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	96/289 (33%)
F09A5.2	NP_001360730.1	PTKc	473..752	CDD:270623	95/281 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000