DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and egl-15

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001300356.1	Gene:	egl-15 / 181291	WormBaseID:	WBGene00001184	Length:	1153	Species:	Caenorhabditis elegans

Alignment Length:	907	Identity:	214/907 - (23%)
Similarity:	339/907 - (37%)	Gaps:	237/907 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   599 KGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRL--------------KRTLQPSD 649
            |.:||.  |::||.:      .|.:..||..||    |.|..|              ..|::..|
Worm    76 KNDQID--KDKIRKD------NNRMMLHLKNID----VSDQGLWSCRVHNAYGQISRNFTVEVID 128

  Fly   650 DVNAIESAEENHI----------QTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQK 704
            ..:.....:.:|:          :..|.||..|  ...::.:...|  ||..|    |.::.::|
Worm   129 FCDYFLFPDIHHLNIPMECVCLWKYNKEAKRSD--VNYAAVTGEVC--SKYAS----RMINRARK 185

  Fly   705 SISNI---FSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHH-----HSSGSDCPTNSSSSSS 761
            .:..|   ..:.|||..:|:...|......::...||....:..     |.| .:.|:.|.:...
Worm   186 PLPMIPCFGDHCKEFDTTPVSDFGLPGKPEDDPLVKRVVLKKDDVIVPVHDS-EESPSESRTEFI 249

  Fly   762 NNNNNNKNTSSNSNHSASQSTIITSTITTTITTT-----------------TTTTPS----KENS 805
            |.:..........::|.||.....:.:|....|.                 |...|:    |.|.
Worm   250 NADEKENKEDEEEDYSVSQPVAPDAGLTELNITAEEPPYFKSNDNIVLFNETHALPAGRTLKLNC 314

  Fly   806 RLK---------FKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCK------QCTKRRRIHPSKSV 855
            |.|         :|..|:.|||.|....:..|...:.|:......      .|....::..:|..
Worm   315 RAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADSGEFHCEALNKVGSAKKY 379

  Fly   856 FDFAKEFEVEQP-----------AGSAADEQFCNCPPAGQKPVKPSV------QISGHKDHPFES 903
            |.......:.:|           :.:..|....:|.....  :.|.:      :|:|  .:.:.:
Worm   380 FHVIIVNRMRRPPIIVPNILANQSVNINDTATFHCKVVSD--LLPHIIWVRINKING--SYSYYN 440

  Fly   904 SSGELDENSDRDIDNDEE-------EEDSASDDVLSMKDH----CYCVPSLAASISLSTNRPLYE 957
            :|.|....:..::|..::       :|.:.:...:|:.|.    |....||..|::   |..|..
Worm   441 NSAEEYMFNYTEMDTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLGMSMA---NATLTV 502

  Fly   958 EEWFHGVLPREEVVRLLNND---------GDF---------LVRETIRNEESQIVLSVCWNG-HK 1003
            .|:.        .:.||..|         .|:         |:..|:..    |:..||... ||
Worm   503 NEFM--------AIHLLTGDEPKIDRWTTSDYIFTTILLFLLLAATLFG----ILFMVCKQTLHK 555

  Fly  1004 H-FIVQTTG----------------EGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRR-- 1049
            . |:..|.|                |.|...:..|.....::|      |.|:|.|..|..:|
Worm   556 KGFMDDTVGLVARKKRVVVSKRPMNEDNENSDDEPSPYQIQII------ETPITKKEAARKQRKR 614

  Fly  1050 ----------------PVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKST---KLDVAVKTCR 1095
                            ||    ||:....:.|:..:|.|.||:|:||..|.|   ::.||||..:
Worm   615 MNSENTVLSEYEVDSDPV----WEVERSKLSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLK 675

  Fly  1096 MTLPDEQKRKFLQEGRILKQY-DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR-------- 1151
            |:..:::....:.|....|.. :|.|:::|||.|....|:.:|:||...|:|..:||
Worm   676 MSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEK 740

  Fly  1152 --KNSN---------------------GLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLV 1193
              |:|.                     .||.|..:......|.||.:|.||..|||||||||.||
Worm   741 AKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLV 805

  Fly  1194 DLEHSVKISDFGMSREE--EEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSK 1256
            ...|.:||||||:||:.  .:|....|..::|:||.|.|||:...||...||||||:|:|||.:.
Worm   806 GDGHVLKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTL 870

  Fly  1257 GDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            |.|||..:........:..||||..|...|:|:|.||..||....|.||.|..|.:.:|.::
Worm   871 GGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWML 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	21/121 (17%)
		TyrKc	1063..1311	CDD:197581	103/284 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/284 (36%)
egl-15	NP_001300356.1	IG_like	41..126	CDD:214653	15/61 (25%)
		Ig	47..126	CDD:299845	15/61 (25%)
		Ig	302..382	CDD:299845	16/79 (20%)
		IG_like	306..384	CDD:214653	15/77 (19%)
		IG_like	401..502	CDD:214653	17/107 (16%)
		Ig3_FGFR	407..503	CDD:143175	17/102 (17%)
		PKc_like	627..933	CDD:304357	109/310 (35%)
		Pkinase_Tyr	640..928	CDD:285015	104/287 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810