DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and abl-1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_509778.2	Gene:	abl-1 / 181261	WormBaseID:	WBGene00000018	Length:	1224	Species:	Caenorhabditis elegans

Alignment Length:	627	Identity:	181/627 - (28%)
Similarity:	272/627 - (43%)	Gaps:	115/627 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   744 HHHSSGSDCPTNSSSSSSNNNNNNKNTSSN---SNHSASQSTIITSTITTTITTTTTTTPSKENS 805
            |.||:|.:.           |:|...|..:   ....||..:.|:|.:...|        .:..|
Worm     3 HSHSTGKEI-----------NDNELFTCEDPVFDQPVASPKSEISSKLAEEI--------ERSKS 48

  Fly   806 RLKFKV-PKIQKKSKAIRNTF------RSKLLNFQLKRSK----PCKQCTKRRRIHPSKSV---- 855
            .|..:| |:.....:..|.||      .|....|:..:|:    .|........:|...:|
Worm    49 PLILEVSPRTPDSVQMFRPTFDTFRPPNSDSSTFRGSQSREDLVACSSMNSVNNVHDMNTVSSSS 113

  Fly   856 ----------FDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDE 910
                      :||....| ||.:....|:                |:|.|:..:. |.....|..
Worm   114 SSSAPLFVALYDFHGVGE-EQLSLRKGDQ----------------VRILGYNKNN-EWCEARLYS 160

  Fly   911 NSDRDIDNDEEEEDSASDDVLSMKDHCYCVPS--LAASISLSTNRPLYEEEWFHGVLPREEVVRL 973
            ....|..|.....:..            .|||  :|...||.      :..|:||.:.|.:...:
Worm   161 TRKNDASNQRRLGEIG------------WVPSNFIAPYNSLD------KYTWYHGKISRSDSEAI 207

  Fly   974 LNN--DGDFLVRETIRNEESQIVLSVCWNG---HKHFIVQTTGEGNFRFEGPPFASIQELI-MHQ 1032
            |.:  .|.|||||: .....|..:||..:|   |....|..| |..|..:...|.::.||: .|.
Worm   208 LGSGITGSFLVRES-ETSIGQYTISVRHDGRVFHYRINVDNT-EKMFITQEVKFRTLGELVHHHS 270

  Fly  1033 YHSE-------LPVTVKS---GAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKL 1087
            .|::       .|.:.|.   |.....|...:.|||...::::..::|.|.:||||:...|....
Worm   271 VHADGLICLLMYPASKKDKGRGLFSLSPNAPDEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDC 335

  Fly  1088 DVAVKTCR---MTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTY 1149
            .:|||..:   |.|     .:||.|..|:|...|.|:|:|:|:|..:.|..|:.|.:..|:||.|
Worm   336 TIAVKALKEDAMPL-----HEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEY 395

  Fly  1150 LRKNSNGLTTR-QQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEE 1211
            ||:....|... ..:.|....|:||.|||:::.||||||||||||...:.|||:|||::|  :|:
Worm   396 LRRTDKSLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKED 460

  Fly  1212 EYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTG 1276
            .|....|.| .|:||||||.|.|..::|..|||::|:|:|||.:.|..||.|:..|.....::.|
Worm   461 TYTAHAGAK-FPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENG 524

  Fly  1277 YRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            :||..|:..|..:||||||||......||.|.:|:..::.||
Worm   525 FRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENLI 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/98 (26%)
		TyrKc	1063..1311	CDD:197581	102/253 (40%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/253 (41%)
abl-1	NP_509778.2	SH3_Abl	119..185	CDD:212784	16/95 (17%)
		SH2_ABL	190..283	CDD:198189	25/100 (25%)
		PTKc_Abl	304..566	CDD:270645	106/267 (40%)
		Pkinase_Tyr	311..562	CDD:285015	103/256 (40%)
		FABD	1091..1224	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810