DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and sem-5

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_509342.1	Gene:	sem-5 / 181055	WormBaseID:	WBGene00004774	Length:	228	Species:	Caenorhabditis elegans

Alignment Length:	163	Identity:	37/163 - (22%)
Similarity:	62/163 - (38%)	Gaps:	46/163 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   898 DHPFESSSGELDE------NSDRDIDNDEEEEDSASDDVLSMKDHCY---------CVPSLAASI 947
            :|.|:  :|..||      |:.:.::.||:             .|.|         .:||....:
Worm     6 EHDFQ--AGSPDELSFKRGNTLKVLNKDED-------------PHWYKAELDGNEGFIPSNYIRM 55

  Fly   948 SLSTNRPLYEEEWFHGVLPREEVVRLLN----NDGDFLVRETIRNEESQIVLSVCW-NGHKHFIV 1007
            :        |..|:.|.:.|.:...||.    .||.||||: ..:...:..:||.: :..:||.|
Worm    56 T--------ECNWYLGKITRNDAEVLLKKPTVRDGHFLVRQ-CESSPGEFSISVRFQDSVQHFKV 111

  Fly  1008 QTTGEGNFRFEGPPFASIQELIMHQYHSELPVT 1040
            .....|.:......|.|:.||:  .||....|:
Worm   112 LRDQNGKYYLWAVKFNSLNELV--AYHRTASVS 142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	24/90 (27%)
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
sem-5	NP_509342.1	SH3_GRB2_like_N	2..53	CDD:212738	12/61 (20%)
		SH2_Grb2_like	56..151	CDD:199828	25/98 (26%)
		SH3_GRB2_like_C	158..210	CDD:212739
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000