DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and ddr-1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_508926.2	Gene:	ddr-1 / 180817	WormBaseID:	WBGene00016104	Length:	766	Species:	Caenorhabditis elegans

Alignment Length:	811	Identity:	162/811 - (19%)
Similarity:	267/811 - (32%)	Gaps:	262/811 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   579 HIYADLELDKKKDTSP-----SPECKGEQIQ--PKKEQ-----IRIEIN----------QTAPQN 621
            |:|.|...|   .|:|     .|.....:|:  |..:.     :|.||:          .|.|..
Worm   133 HVYMDGNFD---TTTPVIRVLDPPIVASRIRFVPSSKNTRTVCMRAEIHGCKHEGVTYYSTVPDG 194

  Fly   622 SIDAHLDRIDELNRVLDDR-------LKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSS 679
            |   .||.:|..:.:.:|.       :||.|....|....::                |..:::.
Worm   195 S---RLDTLDFKDSMFEDSQIYTESGIKRGLGLLTDGFVAQA----------------SPFEKNQ 240

  Fly   680 SSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQH 744
            .::|....::||:.. :.::.|.       |..:..|:...|...| |.|     |......||
Worm   241 MNNSWIGWNRDTTDG-RITILFE-------FEEVHNFTDVVLATFG-NRI-----DGIDVIFSQ- 290

  Fly   745 HHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKF 809
               .|...|..|..|||...:.| |||                                 .|..|
Worm   291 ---DGKTFPLFSQISSSERQSLN-NTS---------------------------------RRYDF 318

  Fly   810 KVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADE 874
            :||...:..:.:|         ..:|.|......|:   :| ..|..:.....|...|..|||.:
Worm   319 RVPLHNRAGRKVR---------ISIKFSSDWMFLTE---VH-FTSAANLTLLSEKIPPPSSAATQ 370

  Fly   875 Q-----------------FCNCPPAGQKPVKPSVQISGHKD------------HPFESSSGELDE 910
            |                 :|......::....||..:..||            |.| .|:|:| .
Worm   371 QLLVVCGIIFLTIFACVAYCVSVCLKRRQKNKSVDSNVKKDLIITHMGNKPTCHVF-PSNGKL-S 433

  Fly   911 NSDRDIDNDEEEEDSASDDVLSMKD----HCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVV 971
            |...::.||.....|....:||:..    .|..:|......:........||..:...:..|.
Worm   434 NGHYEVANDILYARSQKSTLLSVSSKSTFSCRAIPPTWTDFNFPPPPEGREEHTYSQPVSPEN-- 496

  Fly   972 RLLNNDGDF-LVR--ETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQY 1033
               :::|.: .||  :.::...|..:|          |.:..|||.       |..|:|.|:
Worm   497 ---SSNGSYKSVRKIQALKKYPSSALL----------IGKAIGEGK-------FTMIKECII--- 538

  Fly  1034 HSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTL 1098
                                                    ||.: |...||||.:..|...| .|
Worm   539 ----------------------------------------FGGL-KCAHKSTKEEDCVHGTR-AL 561

  Fly  1099 PDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQM 1163
            .|| ....||.||      ||.||:|.|:   .:...:::|.|..|.:..:...:...|.|...:
Worm   562 GDE-IACLLQCGR------HPRIVELFGV---DESYNLLLEHVEYGCIRNFWMASEAPLDTEFLV 616

  Fly  1164 GMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKI-SDFGMSREEEEYIVSDGMKQIPVKWT 1227
            .:|:|..:.|.||||...:|......|.|:|.|...|: |..|.|...:            ::::
Worm   617 RICKDIYSAMAYLESIRIVHGHFTPNNILMDGEFHAKVCSPRGPSHHAQ------------LRYS 669

  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEI-FSKGDTPYSGMTNSRARERIDTGYR------------M 1279
            |||::...::|...|.|:....::|: :.....||..:||.:.   :|....            |
Worm   670 APESIVNNEFTHKSDAWAVATTVYEMAYQCRQRPYEELTNEQI---VDNACALLDHQPNAVVPLM 731

  Fly  1280 PTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            ||..:  .|:.:|:.:|:..|...||.|:.:
Worm   732 PTVFN--YEILQLLTRCFRVDQLERPTFERL 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	16/88 (18%)
		TyrKc	1063..1311	CDD:197581	65/262 (25%)
		PTKc_Fes_like	1067..1315	CDD:270637	65/258 (25%)
ddr-1	NP_508926.2	FA58C	27..179	CDD:238014	12/48 (25%)
		FA58C	34..180	CDD:214572	12/49 (24%)
		Pkinase_Tyr	519..761	CDD:285015	74/331 (22%)
		PKc_like	525..762	CDD:304357	72/315 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910