Protein Alignment FER and gcy-22

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_508018.2
• Gene: gcy-22 / 180365
• WormBaseID: WBGene00001547
• Length: 1058
• Species: Caenorhabditis elegans
• Alignment Length: 740
• Identity: 150/740 - (20%)
• Similarity: 251/740 - (33%)
• Gaps: 238/740 - (32%)

  Fly   696 KRSLS-FSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSS 759
            :|.:| .:..|.:....||||.::..:|.:       |..:|:|                |...|
 Worm   207 RRQMSVITNTSYATALRNLKELARVVIVCL-------ESDEARR----------------NLMIS 248

  Fly   760 SSNNNNNNKN---TSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRL----KFKVPKIQKK 817
            .|.|..:...   ..:.|..:...|:....            |..|.:..|    ||.|...||.
 Worm   249 ISENGMDGDEYVYIMAESRRAGFASSFWNG------------TDGKNDLALRAARKFLVMDNQKY 301

  Fly   818 S------KAIRNTFRSKLLNFQLKRSKP---CKQCTKRRRIHPSKS----------VFDFAKEFE 863
            :      :.:|..|           |:|   |..||   .|.|:.|          ::.:|....
 Worm   302 NDTTTFVQEVRAAF-----------SRPPFSCPNCT---NIDPTVSQVGPLGDALLLYAYALNRS 352

  Fly   864 VEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGE--LDENSDR-------DIDND 919
            :.....:....:||...                |...|...:|:  :::||.|       ::|:.
 Worm   353 IATGNPNPTGTEFCEVA----------------KGMEFLGFTGKVIINQNSTRTPLFVVYNLDST 401

  Fly   920 E---------EEEDSASDDVLSMKDHCYCVPSLAA--------SISLSTNRPL-----------Y 956
            :         |:.|.:.|.|.|..::...:.:..|        ::.|||  |:           :
 Worm   402 DKEMIVMQITEDLDDSKDPVASSVNYYITLVATPAQIWDTWGGTVPLST--PICGFTGTDCPKSF 464

  Fly   957 EEEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRF 1017
            .:::...:|.......:|    .:...||||...:.||.   |:..|..|...:|:
 Worm   465 TDQYLAIILGCTAAALVLIIAVISTIVFLVRSKRQEEER---LNQLWQVHFSSLVK--------- 517

  Fly  1018 EGPPFASIQELIMHQYHS-ELPVTVKSGAILRRPVCRER---WELSNDDVVLLERIGRGNFGDVY 1078
              ||    |:..||...| :..||..:...:......||   :.|:||.||..:...|..|
 Worm   518 --PP----QKNTMHSSRSLQSTVTTSTKVTINSKKDTERHSFYFLNNDSVVARKHNFRATF---- 572

  Fly  1079 KAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLG 1143
                  ||.|.|:                  .|.::..|:.|:.|.||:.:....::.:......
 Worm   573 ------TKNDRAM------------------FRKMRNVDNDNLCKFIGLSLDSPTLISIWRYCSR 613

  Fly  1144 GSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYL-ESKNCIHRDLAARNCLVDLEHSVKISDFGMS 1207
            |||...:.|.|..:....:..:.||.|..:.|| .|....|..|::..||||....||:|.||:|
 Worm   614 GSLQDVIAKGSLQMDWFFKYSLMRDVADAIYYLHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLS 678

  Fly  1208 REEEEYIVSDGMKQIPVK------WTAPEALNFGKYTSL-----CDVWSYGILMWEIFSK---GD 1258
                      .:||..||      .||||.:   :.|:|     .|::|:.|:..|:.:|   .|
 Worm   679 ----------AIKQYEVKEQRDFLHTAPEHI---RDTNLPITKEMDIYSFAIICSELITKKSAWD 730

  Fly  1259 TPYSGMTNSRARERIDTGYRMPTPKSTPEE------MYRLMLQCWAADAESRP------------ 1305
            .............:|..|.|.|...|...|      |..|:..||..:.:.||
 Worm   731 LENETFDIEELVYKIKKGGRSPPRPSLETEDEHNGSMSLLVRDCWNENPDQRPTSEQIKTLMKSM 795

  Fly  1306 -H------FDEIYNVVDALILRLDN 1323
             |      .|.::||::.....|::
 Worm   796 NHNRSSNLMDHVFNVLEQYASNLED 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	19/101 (19%)
		TyrKc	1063..1311	CDD:197581	67/287 (23%)
		PTKc_Fes_like	1067..1315	CDD:270637	67/287 (23%)
gcy-22	NP_508018.2	Periplasmic_Binding_Protein_Type_1	28..408	CDD:299141	45/265 (17%)
		ANF_receptor	48..399	CDD:279440	44/256 (17%)
		PKc_like	553..795	CDD:304357	68/282 (24%)
		HNOBA	<791..852	CDD:285003	5/30 (17%)
		CYCc	831..1023	CDD:214485
		Guanylate_cyc	858..1044	CDD:278633

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900