DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and gcy-7

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001360539.1	Gene:	gcy-7 / 179222	WormBaseID:	WBGene00001534	Length:	1117	Species:	Caenorhabditis elegans

Alignment Length:	224	Identity:	55/224 - (24%)
Similarity:	93/224 - (41%)	Gaps:	31/224 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1100 DEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMG 1164
            |:.|..|:   |.|:..|..|:.:.||:|:....::.|......||:...:.|.:..:.......
Worm   600 DDDKCTFM---RSLRNLDQDNLNRFIGLCLDGPQMLSVWRFCSRGSIADVILKATIQMDNFFIYS 661

  Fly  1165 MCRDAAAGMRYLE-SKNCIHRDLAARNCLVDLEHSVKISDFGMS--REEEEYIVSDGMKQIPVKW 1226
            :.:|...|:.:|. |....|..|.::.||:|....||||::|:.  |..|.|...|      :.|
Worm   662 LIKDMVHGLVFLHGSMVGYHGMLTSKCCLIDDRWQVKISNYGLQDLRSPEMYEKKD------LLW 720

  Fly  1227 TAPEALNFG--KYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEM 1289
            :|||.|...  |.:...||:|.||:..|:.::     .|:.|...|            |..|||:
Worm   721 SAPELLRAEDIKGSKEGDVYSLGIICAELITR-----KGVFNMEDR------------KEDPEEI 768

  Fly  1290 YRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            ..|:.:...........:|....:..||:
Worm   769 IYLLKKGGLKSPRPDLEYDHTIEINPALL 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	53/215 (25%)
		PTKc_Fes_like	1067..1315	CDD:270637	53/219 (24%)
gcy-7	NP_001360539.1	PBP1_NPR_GC-like	36..438	CDD:380575
		PKc_like	550..822	CDD:389743	55/224 (25%)
		CYCc	860..1049	CDD:214485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900