DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and ark-1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001255654.1	Gene:	ark-1 / 178218	WormBaseID:	WBGene00000186	Length:	1043	Species:	Caenorhabditis elegans

Alignment Length:	263	Identity:	98/263 - (37%)
Similarity:	145/263 - (55%)	Gaps:	14/263 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly  1061 DDVVLLERIGRGNFGDVYKAKLK----STKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNI 1121
            :.:.|.:.:|:|.||.|::|..|    |..:.||||.............||||..|:.:..|.::
Worm   111 EKITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHV 175

  Fly  1122 VKLIGICVQKQPIMIVMELVLGGSLLTYLRKNS--NGLTTRQQMGMCRDAAAGMRYLESKNCIHR 1184
            |:|.|:.:..:.||:|.||...||||..|.|.:  :..............|.||.|||.:..|||
Worm   176 VRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHR 240

  Fly  1185 DLAARNCLVDLEHSVKISDFGMSRE---EEEYIVSD---GMKQIPVKWTAPEALNFGKYTSLCDV 1243
            ||||||.||.....|||||||:||.   .|:|..|:   .:| :|:.|.|||.:||.|:||..||
Worm   241 DLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLK-LPIAWCAPECINFLKFTSKSDV 304

  Fly  1244 WSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPT-PKSTPEEMYRLMLQCWAADAESRPHF 1307
            |:||:.:||:||.|:.|:.|.:.::..|.:|....:.| ||:.||::|.::.:.|....:.||.|
Worm   305 WAYGVTIWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTF 369

  Fly  1308 DEI 1310
            .:|
Worm   370 SDI 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	98/261 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/257 (38%)
ark-1	NP_001255654.1	SAM_superfamily	14..71	CDD:301707
		TyrKc	113..376	CDD:197581	98/261 (38%)
		PTKc_Ack_like	117..378	CDD:270636	97/257 (38%)
		SH3	384..434	CDD:214620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910