DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and kin-24

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_501761.2	Gene:	kin-24 / 177829	WormBaseID:	WBGene00002206	Length:	516	Species:	Caenorhabditis elegans

Alignment Length:	408	Identity:	113/408 - (27%)
Similarity:	203/408 - (49%)	Gaps:	48/408 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   952 NRPLYEEEWFHGVLPREEVVRLLNND--GDFLVRETIRNEESQIVLSVCW-----------NGHK 1003
            |..::..:.:|||..:|||..|:..:  |.||.|...  .:|.:.|::..           |.|.
Worm    21 NSRVHNLKCYHGVQKKEEVANLMRGERPGTFLFRSCF--VKSGVALALFLSVKVRAGDSDANIHH 83

  Fly  1004 HFIVQTTGEGNF-----------RFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWE 1057
            :.:....||...           ..|...|.:::|||.|..|..|...::.|    ||:.|..|:
Worm    84 YQVEDRAGEYYLMQELMEKEELVTRESKAFPTLEELIGHFQHHRLACKIRLG----RPLKRPSWQ 144

  Fly  1058 LSNDDVVLLE--RIGRGNFGDVYKAKLKSTK--LDVAVKTCRMTLPD-----EQKRKFLQEGRIL 1113
            |.::.||..:  ::|.|||..||:..|:...  :.||:|..:.:..:     |.:...|.|.||:
Worm   145 LRHNSVVYDDTGKLGSGNFCIVYRGMLRKQGKIIPVAIKVSKNSDKESAALMETRNLLLAEARIM 209

  Fly  1114 KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLES 1178
            ..|::.|::::.|:.....|.|:.||...||||...|:|....:...::..:..|||.|||||..
Worm   210 MNYNNINVIRIYGVACDVPPFMVCMEFCSGGSLEDALKKYGKDMEEFERQILLIDAARGMRYLHD 274

  Fly  1179 KNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEAL-NFGKYTSL 1240
            |.|:|||||:||||:..:..|||:|||:|:  |:::....:.:|:.|:.|.|||.: ...::::.
Worm   275 KKCVHRDLASRNCLISFDGIVKIADFGLSKTLEKDQKAFKEALKEAPLAWLAPECIQRESEFSTK 339

  Fly  1241 CDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPE--EMYRLMLQCWAADAES 1303
            .|||::|::::|:::..:..::|..:.....:|... .|||.::..:  .|..::...|....:.
Worm   340 TDVWAFGVVIFEVYNNAEKLFAGEEDIAILRKIKKA-NMPTIENRTKVPAMQAVLSSIWTRKPDD 403

  Fly  1304 RPHFDEIYNVVDALILRL 1321
            ||   |:..|::.|:..|
Worm   404 RP---EMQKVLEKLVAAL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/109 (23%)
		TyrKc	1063..1311	CDD:197581	78/261 (30%)
		PTKc_Fes_like	1067..1315	CDD:270637	77/261 (30%)
kin-24	NP_501761.2	SH2	29..128	CDD:214585	24/100 (24%)
		PTKc	157..414	CDD:270623	77/260 (30%)
		STYKc	157..414	CDD:214568	77/260 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167368
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.800