DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and kin-21

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_501758.2	Gene:	kin-21 / 177826	WormBaseID:	WBGene00002204	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	483	Identity:	133/483 - (27%)
Similarity:	210/483 - (43%)	Gaps:	101/483 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   873 DEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDN---DEEEEDSASDDVLSMK 934
            |::.|....:......|::.|.|             ...|:.|:..   |.|...|..|.||:::
Worm     5 DQKSCETAESSNTKYSPNLVIDG-------------AAVSNEDVAGKVADLEYAHSFPDLVLNVE 56

  Fly   935 DHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRE-----------TIRN 988
            .|   ......|..|..|       |:||::..:...:||..:..::||.           |.|.
Worm    57 KH---DDEYIKSFLLQRN-------WYHGMMFGKAAEKLLKWESSYIVRRSMGPTHKFLCITARV 111

  Fly   989 EESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPV--------TVKSGA 1045
            |:........||          .||   :..|        |:::....:||        .:.:.:
Worm   112 EDKYFHFQFNWN----------SEG---WSCP--------ILYEKFPRIPVKRYEHIYQLLDAWS 155

  Fly  1046 ILRR---PVCRERWELSNDDVVLLERIGRGNFGDVYKAKL----KSTKLDVAVKTCRMTLPDEQK 1103
            ::..   |:.|....|.:..:.|..::|||.||:|.|||.    .:...:||||    .|..:.|
Worm   156 LVVNQLVPISRCSMILQHSSIALENQLGRGAFGEVIKAKYVPMGATVPTEVAVK----RLIGDAK 216

  Fly  1104 R----KFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMG 1164
            |    .|..|..|:...:|.|||.|.|....:||||:|:|.|.||.|..||::..| :.::|.:.
Worm   217 RPQLVDFCNEANIMTLLEHKNIVALYGFASLQQPIMLVIEFVPGGDLRKYLQRTPN-VPSKQIIK 280

  Fly  1165 MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAP 1229
            ...:.|:||::|.|||.|||||||||||:..|.:|||||||:|..|.|..:. .:|:.|::|.:|
Worm   281 FAMEIASGMKHLSSKNVIHRDLAARNCLITKELNVKISDFGLSVNESETKMK-SLKKAPIRWLSP 344

  Fly  1230 EALNFGKYTSLCDVWSYGILMWEIFSK-GDTP---------YSGMTNSRARERIDTGYRMPTPKS 1284
            |..:.|.:....||||||:|:.|:.:: ...|         ...:..|....:|:.|
Worm   345 ETFSKGLFNEKTDVWSYGVLLTELMTRCAHDPLWPKNLKQVQKWIKESEHPHKIEDG-------- 401

  Fly  1285 TPEEMYRLMLQCWAADAESRPHFDEIYN 1312
            .|.|:..::..|.|.....|.:|.|:.|
Worm   402 DPSELKEIVDACCAKIPSVRINFREVKN 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	16/96 (17%)
		TyrKc	1063..1311	CDD:197581	94/265 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	94/264 (36%)
kin-21	NP_501758.2	SH2	71..146	CDD:214585	19/102 (19%)
		TyrKc	178..431	CDD:197581	95/266 (36%)
		PTKc	180..432	CDD:270623	94/264 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870