DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and kin-26

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_501309.1	Gene:	kin-26 / 177575	WormBaseID:	WBGene00002208	Length:	433	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	134/392 - (34%)
Similarity:	215/392 - (54%)	Gaps:	32/392 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   942 SLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVR--ETIRNEESQIVLSVCWNGH-- 1002
            ||.:.:|   |..:.:|.::||:||.|:|.:||:|:||||:|  |.........:|||.:|..
Worm     5 SLPSEVS---NATIDKELYYHGLLPSEDVRQLLSNNGDFLLRSSEPEPGSPRTHILSVMFNNRLD 66

  Fly  1003 -----KHFIVQTTGEGNFRFEGPPFASIQELI-MHQYHSELPVTVKSGAILRRPVCRERWELSND 1061
                 |||:|.......|..:...|.|||::: .:|.::   ..:|.|.:|..|:.|:.|||.:|
Worm    67 DINSIKHFVVNFVDGKYFINDKMSFPSIQKMLGTYQRNN---TEIKEGCMLVNPIRRQFWELEHD 128

  Fly  1062 DVVLLERIGRGNFGDVYKAKLKSTK----LDVAVKTCRMTLPDEQKRK-FLQEGRILKQYDHPNI 1121
            .:.:.:::|.|.||:|....:|..|    :.||:|..::....:.|.| ||.|.|.:::..|.||
Worm   129 QITIHKKLGEGAFGEVSSGVMKFKKGMKTVQVAIKQVKLDKTGKAKIKDFLAEARTMRKLGHQNI 193

  Fly  1122 VKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDL 1186
            :|..|:.|.::|:.:||||.:.|:|.::|:||.: |:..::..|...||.|:.|:..|..:|||:
Worm   194 IKFYGVGVLQEPLYLVMELAVNGALDSFLKKNED-LSVDKKTEMILQAAWGLEYIHGKPMLHRDI 257

  Fly  1187 AARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLC----DVWSYG 1247
            ||||||. .:..|||||||::|....|.:....|. |::|.|.|.:.    |.:|    |||:||
Worm   258 AARNCLY-TDGKVKISDFGLTRNGTVYQIKPNTKS-PIRWLAIETIK----TMICSEKTDVWAYG 316

  Fly  1248 ILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYN 1312
            :|.||||:....||.||..:....::..|||||.......|:..:|.:|.|.:...||...||..
Worm   317 VLCWEIFNNAAEPYPGMKPADVATQVANGYRMPPYPHAQAEIQTMMARCNAENPNDRPSMAEIAE 381

  Fly  1313 VV 1314
            ::
Worm   382 IL 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/95 (32%)
		TyrKc	1063..1311	CDD:197581	90/256 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	91/257 (35%)
kin-26	NP_501309.1	SH2_Fps_family	15..108	CDD:198224	30/95 (32%)
		TyrKc	130..383	CDD:197581	91/259 (35%)
		PTKc	134..384	CDD:270623	91/257 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810