DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and C55C3.4

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_500846.1	Gene:	C55C3.4 / 177346	WormBaseID:	WBGene00016954	Length:	431	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	131/373 - (35%)
Similarity:	213/373 - (57%)	Gaps:	27/373 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   951 TNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVR--ETIRNEESQIVLSVCWNGHK-----HFIVQ 1008
            |::.|..::::||:||||::..:||..|.||:|  |.::.|:.|.||||.  |.|     ||:|:
Worm     2 TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVV--GEKNTSANHFVVR 64

  Fly  1009 TTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSG---AILRRPVCRERWELSNDDVVLLERIG 1070
             ..:.....:...|.:|.||:.|...::...:.|.|   .:|:..|.|::|||.::||.|.:::|
Worm    65 -EADHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKVVLKHAVERQKWELYHEDVELTKKLG 128

  Fly  1071 RGNFGDVYKAKLKSTKLD-------VAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGI 1127
            .|.||:|:|.||... ||       |||||.:: ::..||.::.::|.|:::..||.|:||..|:
Worm   129 EGAFGEVWKGKLLKI-LDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGV 192

  Fly  1128 CVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCL 1192
            ....:|:.::|||..||:|.:.|.|....:..:.:  :...||.|:.|:..||.:|||:||||||
Worm   193 AAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE--LIYQAANGLAYIHEKNLMHRDVAARNCL 255

  Fly  1193 VDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKG 1257
            .. ...|||:|||:|||..:|.: |..|::|::|..||.:..|.||...||:::|::.|||...|
Worm   256 YG-GGQVKIADFGLSREGADYTM-DLKKKVPIRWLPPETIRSGLYTPKTDVFAFGVMAWEITEDG 318

  Fly  1258 DTPYSGMTNSRARERIDTGYRMP-TPKSTPEEMYRLMLQCWAADAESR 1304
            ..||.|........::..||||| :|:...|....::.:||....|.|
Worm   319 KEPYPGFKVIEVAMKVLQGYRMPFSPEVNKEFAEFILTKCWPEKYEDR 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/92 (33%)
		TyrKc	1063..1311	CDD:197581	91/251 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	89/247 (36%)
C55C3.4	NP_500846.1	SH2_Fps_family	4..93	CDD:198224	30/91 (33%)
		TyrKc	121..376	CDD:197581	91/251 (36%)
		PTKc	125..374	CDD:270623	89/247 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810