Protein Alignment FER and toca-2

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_499838.2
• Gene: toca-2 / 176812
• WormBaseID: WBGene00010663
• Length: 610
• Species: Caenorhabditis elegans
• Alignment Length: 598
• Identity: 116/598 - (19%)
• Similarity: 223/598 - (37%)
• Gaps: 137/598 - (22%)

  Fly    15 ALIVRQDAELRLMETMKRSIQMKAKCDKEYAISLTAVAQQ-GLKIDRADEMQGSL-ISKSWRSYM 77
            ||:......:...|.:.:..:.||..::||:..|.::|:: ..|.:..||:..|: .:.|:.|::
 Worm    16 ALLSYTQKGIDFFEKLGQFSKEKAAIEEEYSTKLRSLAKKYAKKSEEDDEILKSVSYTSSFNSFL 80

  Fly    78 DELDHQAKQFKFNAEQL-----EVVCDKLTHLSQDKRKARKAYQEEHAKIAARLNHLTDEVVRKK 137
            .:||..|.:.:.:||.:     ..|..|...:...::.|....:..:.|:..::|.:.      |
 Worm    81 QQLDQIATRHQTSAEHIRGGVVSYVASKTCQMRSSRKNAINDLKTINDKLEDQINEMC------K 139

  Fly   138 SEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQKACRKLHLTHNE--------YVLSI 194
            |. :.:|:.:|.....:::.|     ::.:.|:..|.:.:|| |.|....||        |...:
 Worm   140 SG-KCYLKSFKDAENSYQKFY-----KADKNLEISRLELEKA-RALANARNEACELAKQDYSALV 197

  Fly   195 TEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRIDTVIGSI 259
            .:....:|.:...|||.:....::|.:..|...|.:||:...:.|..||..:|.:|.:...:|.|
 Worm   198 RKTNAEQKRYHVELLPVIFARLKAVDKECIADMRQVLQKIVSFDDSLADSTEECRKIMQREVGKI 262

  Fly   260 NPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRLQELEGAVRD 324
            :...:             ..|:.:..|..|:      |.:...:::|             |..::
 Worm   263 DAEGD-------------AQLVLKSVEATIE------QPAPFEIEDL-------------GDPKN 295

  Fly   325 CQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQ-----------------SNKDSLCRQSKDL 372
            |..:       .|..:..:.|.::.:..:.:..|:                 ||.|.|....|..
 Worm   296 CDSR-------TNDSADGSGGKLLKSSPSKNRIIRNFLGILKEKEADEKPEASNNDQLMYTDKSK 353

  Fly   373 NA---LRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNST-SSP 433
            .|   |.|   .:.|:.||      |...|:...|.:....|:|.:    |.|.|..:.|. :.|
 Worm   354 PAHVRLSC---LRSKIRDM------EKQLEQAIQGREGITRLQQAY----YTNPQHGNPSACTEP 405

  Fly   434 GLGIMNELMRRGGVLTLLR------------GRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQ 486
            .:....::.:....:..|:            |:.|.|..:.||.    .|||..|       .|.
 Worm   406 LISYAKKIEKLKMDIHNLKEFYAMLEMSVEEGQERSFGGRDTPD----TTRSMSG-------SST 459

  Fly   487 SLGSLSVIRD---GNGPSPARYEPITNHRLRQA-ASVHYLGEEIATSSTNPPDLTRLRRTQCSML 547
            :..|...|.|   |...:.:..:..:.:.|||. .:...|.....||.::.|  |.|||.
 Worm   460 NQSSSKTIEDVLSGEAGNSSSADDSSKNILRQLFTTPKRLISSPKTSKSSTP--TPLRRR----- 517

  Fly   548 CLGEDEEPVVLAS 560
              .|...|.:|.|
 Worm   518 --AEISSPKILRS 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	49/242 (20%)
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
toca-2	NP_499838.2	F-BAR_CIP4-like	8..267	CDD:153337	55/263 (21%)
		HR1_CIP4-like	356..431	CDD:212009	16/87 (18%)
		SH3_CIP4-like	551..608	CDD:212844

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910