DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and F57B9.8

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_498511.1	Gene:	F57B9.8 / 175967	WormBaseID:	WBGene00018999	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	375	Identity:	126/375 - (33%)
Similarity:	214/375 - (57%)	Gaps:	29/375 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   957 EEEWFHGVLPREEVVRLLNNDGDFLVR-------------ETIRNEESQIVLSVCWNGHKHFIVQ 1008
            |:.:|||:||||||..||..:||:|:|             ..::||.||.|        .|::::
Worm     5 EQPFFHGLLPREEVKLLLQKNGDYLMRTSEPQGQARHLIISVMQNETSQEV--------AHYVIR 61

  Fly  1009 TTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGN 1073
            |:.......:...|.::.||:.|...:::...|.| ::|..|:.|:.|||::.|:.:.:.:|.|.
Worm    62 TSDGAYSITDKIKFGTLTELVNHHKQAKISEEVAS-SVLVNPIGRQSWELNHADITMTKVLGEGA 125

  Fly  1074 FGDVYKAKLK--STKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIM 1135
            ||:|....||  ||.:|||:|..:: .:..||.::.:.|.|:::.:||.|:||..|:....:|::
Worm   126 FGEVKLGTLKMGSTTVDVAIKVAKLEKVTKEQIKEIITEARLMRGFDHKNVVKCYGVAAIDEPLL 190

  Fly  1136 IVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVK 1200
            :|||||.||:|..||:|||: :...:::.:....|||:.|:.|||.||||:||||.|.. :...|
Worm   191 VVMELVPGGALDKYLQKNSS-VQWPEKLDIIAQVAAGLAYIHSKNIIHRDIAARNILYG-KGVAK 253

  Fly  1201 ISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMT 1265
            :||||:||...||.: |..|::|::|.:||.:....||...||:::.||.||:...|..||..|.
Worm   254 VSDFGLSRVGTEYQM-DPSKRVPIRWLSPETIVSFLYTPQTDVFAFSILCWEVIENGAQPYPEML 317

  Fly  1266 NSRARERID-TGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVV 1314
            ..:..:::. ..||||..:..|..:..::.:||..|.:.||...::..::
Worm   318 VVQVHQKVGRDDYRMPISQKAPAMLADVIKKCWIRDPQQRPTMSQVVQMM 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/94 (29%)
		TyrKc	1063..1311	CDD:197581	90/251 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	90/252 (36%)
F57B9.8	NP_498511.1	SH2_Fps_family	1..91	CDD:198224	27/93 (29%)
		STYKc	115..367	CDD:214568	90/254 (35%)
		PTKc	119..367	CDD:270623	90/250 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810