DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and daf-2

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_001299916.1 Gene:daf-2 / 175410 WormBaseID:WBGene00000898 Length:1928 Species:Caenorhabditis elegans


Alignment Length:1312 Identity:277/1312 - (21%)
Similarity:465/1312 - (35%) Gaps:319/1312 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   159 IKAPSRSGRKLDDVRDKYQ------KACRKLHLTHNEYVLSITEAIEVEKDFRNVLLPGLLEHQQ 217
            |||  .:|...|...|.||      :.|||. :...|.|..|...|:.....:.:.|..:::   
 Worm   458 IKA--TAGLCSDKCPDGYQINPDDHRECRKC-VGKCEIVCEINHVIDTFPKAQAIRLCNIID--- 516

  Fly   218 SVQESFILLWRNILQEAAQYGDLT-----------ADKYKEIQKRIDTVIG-------------- 257
                                |:||           |.:.|:|...|.|:.|              
 Worm   517 --------------------GNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLN 561

  Fly   258 ---SINPTEEYGEFTEKYK----TSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRL 315
               ::...|....|...|.    .:|....|  ||.|           :.||:|..||....|::
 Worm   562 MFRNLRRIEAKSLFRNLYAITVFENPNLKKL--FDST-----------TDLTLDRGTVSIANNKM 613

  Fly   316 QELEGAVRDCQEK------QMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNA 374
            ...: .::....|      .:...|..||...:.....| |.|.|:    .|.||:.......|.
 Worm   614 LCFK-YIKQLMSKLNIPLDPIDQSEGTNGEKAICEDMAI-NVSITA----VNADSVFFSWPSFNI 672

  Fly   375 LRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQ------NFIENGYNNEQQRSNSTSSP 433
            ..         :|..|....|:..:|:|. .|:::|:|:      :..::.:....:.||...:|
 Worm   673 TD---------IDQRKFLGYELFFKEVPR-IDENMTIEEDRSACVDSWQSVFKQYYETSNGEPTP 727

  Fly   434 GL------------------GIMNELMRRGGVLTLLRGRGRHFKRKS--TPQPAT-PMTRSRQGR 477
            .:                  .:..:::...|....:...|  |.|.|  ||.|.| .:.:.....
 Worm   728 DIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNGVSKIG--FVRTSYYTPDPPTLALAQVDSDA 790

  Fly   478 FN-----KLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLT 537
            .:     .|||.. .|...:::...|..||  ||.               .|:..|.::.|.:..
 Worm   791 IHITWEAPLQPNG-DLTHYTIMWRENEVSP--YEE---------------AEKFCTDASTPANRQ 837

  Fly   538 RLRRTQCSMLCLGEDEEPVVLASPA--PLTQLTAAVLTNTNNNHIYADLELDKKKDTSPSPE-CK 599
            ..:          :.:|.:|...|.  |.::..|..|.....:.       |::|..:.:|. |.
 Worm   838 HTK----------DPKETIVADKPVDIPSSRTVAPTLLTMMGHE-------DQQKTCAATPGCCS 885

  Fly   600 GEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQP-----SDDVNAIESAEE 659
            ...|:...||.:.:  :..|.::|::....    |::||:    .|.|     :|.|........
 Worm   886 CSAIEESSEQNKKK--RPDPMSAIESSAFE----NKLLDE----VLMPRCDIKNDPVGCAMLLLP 940

  Fly   660 NHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFS-NLKEFSKSPLVR 723
            ..|....:..|.:.....|.......|:|:.....|::.|..|...|..|.| ..||:.:...:.
 Worm   941 PEIDDSDVGDDDEEPGGGSEQQQRILRNSEILKRQKRQILGRSLGGIHGIRSIGRKEYEQFADMI 1005

  Fly   724 MGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTI 788
            :....:....:||.|.........:....|..........:.:.|..||:|..|....||.:   
 Worm  1006 LDTMRVRRSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHISKKKPSSSSTTSTPAPTIAS--- 1067

  Fly   789 TTTITTTTTTTPSKENSRLKFKVPKIQK----------------KSKAIRNTFRSKLLNFQLKRS 837
            ...:|...||.|.     .:.::.:|.:                .|..|||.....|....|...
 Worm  1068 MYALTRKPTTVPG-----TRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHYTLYAISLSAC 1127

  Fly   838 K----PCKQCTKRRR---IHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISG 895
            :    |...|:...|   :..:|.:.|      :::......:.:|.|          .|.|::.
 Worm  1128 QNMTVPGASCSISHRAGALKRTKHITD------IDKVLNETIEWRFMN----------NSQQVNV 1176

  Fly   896 HKDHPFESSSG------ELDENSDRDI-----DNDEEEEDSASDDVL--SMKDHCYCVPSLAASI 947
            ..|.|.|.:.|      :|....|..|     ...:....:.:..||  ::.|..|.|...|.|:
 Worm  1177 TWDPPTEVNGGIFGYVVKLKSKVDGSIVMTRCVGAKRGYSTRNQGVLFQNLADGRYFVSVTATSV 1241

  Fly   948 SLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGE 1012
                          ||..|..|       ..|.:|..|......:|:|.:.    ..|::..:..
 Worm  1242 --------------HGAGPEAE-------SSDPIVVMTPGFFTVEIILGML----LVFLILMSIA 1281

  Fly  1013 G-------NFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIG 1070
            |       ..|: |....::.:.:  |.:.|..|..|..|        :.|||..|||||.::.|
 Worm  1282 GCIIYYYIQVRY-GKKVKALSDFM--QLNPEYCVDNKYNA--------DDWELRQDDVVLGQQCG 1335

  Fly  1071 RGNFGDVY------KAKLKSTKL-DVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGIC 1128
            .|:||.||      ...|...:. ..|:|.........:...:|.|..|:|.:....||||.|:.
 Worm  1336 EGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVI 1400

  Fly  1129 VQKQPIMIVMELVLGGSLLTYLRK------------NSNGLTTRQQMGMCRDAAA----GMRYLE 1177
            ...||.|:|||::..|:|..|||.            |...:..|.:.   .:.||    ||.|||
 Worm  1401 STVQPAMVVMEMMDLGNLRDYLRSKREDEVFNETDCNFFDIIPRDKF---HEWAAQICDGMAYLE 1462

  Fly  1178 SKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSL 1240
            |....|||||||||:::.:.:|||.||||:|:  ..:|....|.:.:||:|.:||:|..||:.|.
 Worm  1463 SLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSK 1527

  Fly  1241 CDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYR-MPTPKSTPEEMYRLMLQCWAADAESR 1304
            .||||:|::::|:.:.|..||.|::|......|....: :..|:......|::|..||......|
 Worm  1528 SDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDR 1592

  Fly  1305 PHFDEIYNVVDA 1316
            |.|.::.:::.|
 Worm  1593 PTFLQLVHLLAA 1604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341 19/100 (19%)
SH2_Fps_family 953..1039 CDD:198224 15/92 (16%)
TyrKc 1063..1311 CDD:197581 90/273 (33%)
PTKc_Fes_like 1067..1315 CDD:270637 87/273 (32%)
daf-2NP_001299916.1 Recep_L_domain 180..305 CDD:279382
Furin-like 360..490 CDD:279142 11/34 (32%)
Recep_L_domain 512..627 CDD:279382 24/151 (16%)
FN3 776..>832 CDD:238020 14/73 (19%)
FN3 1169..1255 CDD:238020 22/116 (19%)
PTKc_InsR_like 1321..1604 CDD:173625 95/285 (33%)
STYKc 1328..1602 CDD:214568 90/276 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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