Protein Alignment FER and daf-2

DIOPT Version :10

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_001299916.1
• Gene: daf-2 / 175410
• WormBaseID: WBGene00000898
• Length: 1928
• Species: Caenorhabditis elegans
• Alignment Length: 1312
• Identity: 277/1312 - (21%)
• Similarity: 465/1312 - (35%)
• Gaps: 319/1312 - (24%)

  Fly   159 IKAPSRSGRKLDDVRDKYQ------KACRKLHLTHNEYVLSITEAIEVEKDFRNVLLPGLLEHQQ 217
            |||  .:|...|...|.||      :.|||. :...|.|..|...|:.....:.:.|..:::
 Worm   458 IKA--TAGLCSDKCPDGYQINPDDHRECRKC-VGKCEIVCEINHVIDTFPKAQAIRLCNIID--- 516

  Fly   218 SVQESFILLWRNILQEAAQYGDLT-----------ADKYKEIQKRIDTVIG-------------- 257
                                |:||           |.:.|:|...|.|:.|
 Worm   517 --------------------GNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLN 561

  Fly   258 ---SINPTEEYGEFTEKYK----TSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRL 315
               ::...|....|...|.    .:|....|  ||.|           :.||:|..||....|::
 Worm   562 MFRNLRRIEAKSLFRNLYAITVFENPNLKKL--FDST-----------TDLTLDRGTVSIANNKM 613

  Fly   316 QELEGAVRDCQEK------QMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNA 374
            ...: .::....|      .:...|..||...:.....| |.|.|:    .|.||:.......|.
 Worm   614 LCFK-YIKQLMSKLNIPLDPIDQSEGTNGEKAICEDMAI-NVSITA----VNADSVFFSWPSFNI 672

  Fly   375 LRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQ------NFIENGYNNEQQRSNSTSSP 433
            ..         :|..|....|:..:|:|. .|:::|:|:      :..::.:....:.||...:|
 Worm   673 TD---------IDQRKFLGYELFFKEVPR-IDENMTIEEDRSACVDSWQSVFKQYYETSNGEPTP 727

  Fly   434 GL------------------GIMNELMRRGGVLTLLRGRGRHFKRKS--TPQPAT-PMTRSRQGR 477
            .:                  .:..:::...|....:...|  |.|.|  ||.|.| .:.:.....
 Worm   728 DIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNGVSKIG--FVRTSYYTPDPPTLALAQVDSDA 790

  Fly   478 FN-----KLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLT 537
            .:     .|||.. .|...:::...|..||  ||.               .|:..|.::.|.:..
 Worm   791 IHITWEAPLQPNG-DLTHYTIMWRENEVSP--YEE---------------AEKFCTDASTPANRQ 837

  Fly   538 RLRRTQCSMLCLGEDEEPVVLASPA--PLTQLTAAVLTNTNNNHIYADLELDKKKDTSPSPE-CK 599
            ..:          :.:|.:|...|.  |.::..|..|.....:.       |::|..:.:|. |.
 Worm   838 HTK----------DPKETIVADKPVDIPSSRTVAPTLLTMMGHE-------DQQKTCAATPGCCS 885

  Fly   600 GEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQP-----SDDVNAIESAEE 659
            ...|:...||.:.:  :..|.::|::....    |::||:    .|.|     :|.|........
 Worm   886 CSAIEESSEQNKKK--RPDPMSAIESSAFE----NKLLDE----VLMPRCDIKNDPVGCAMLLLP 940

  Fly   660 NHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFS-NLKEFSKSPLVR 723
            ..|....:..|.:.....|.......|:|:.....|::.|..|...|..|.| ..||:.:...:.
 Worm   941 PEIDDSDVGDDDEEPGGGSEQQQRILRNSEILKRQKRQILGRSLGGIHGIRSIGRKEYEQFADMI 1005

  Fly   724 MGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTI 788
            :....:....:||.|.........:....|..........:.:.|..||:|..|....||.:
 Worm  1006 LDTMRVRRSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHISKKKPSSSSTTSTPAPTIAS--- 1067

  Fly   789 TTTITTTTTTTPSKENSRLKFKVPKIQK----------------KSKAIRNTFRSKLLNFQLKRS 837
            ...:|...||.|.     .:.::.:|.:                .|..|||.....|....|...
 Worm  1068 MYALTRKPTTVPG-----TRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHYTLYAISLSAC 1127

  Fly   838 K----PCKQCTKRRR---IHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISG 895
            :    |...|:...|   :..:|.:.|      :::......:.:|.|          .|.|::.
 Worm  1128 QNMTVPGASCSISHRAGALKRTKHITD------IDKVLNETIEWRFMN----------NSQQVNV 1176

  Fly   896 HKDHPFESSSG------ELDENSDRDI-----DNDEEEEDSASDDVL--SMKDHCYCVPSLAASI 947
            ..|.|.|.:.|      :|....|..|     ...:....:.:..||  ::.|..|.|...|.|:
 Worm  1177 TWDPPTEVNGGIFGYVVKLKSKVDGSIVMTRCVGAKRGYSTRNQGVLFQNLADGRYFVSVTATSV 1241

  Fly   948 SLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGE 1012
                          ||..|..|       ..|.:|..|......:|:|.:.    ..|::..:..
 Worm  1242 --------------HGAGPEAE-------SSDPIVVMTPGFFTVEIILGML----LVFLILMSIA 1281

  Fly  1013 G-------NFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIG 1070
            |       ..|: |....::.:.:  |.:.|..|..|..|        :.|||..|||||.::.|
 Worm  1282 GCIIYYYIQVRY-GKKVKALSDFM--QLNPEYCVDNKYNA--------DDWELRQDDVVLGQQCG 1335

  Fly  1071 RGNFGDVY------KAKLKSTKL-DVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGIC 1128
            .|:||.||      ...|...:. ..|:|.........:...:|.|..|:|.:....||||.|:.
 Worm  1336 EGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVI 1400

  Fly  1129 VQKQPIMIVMELVLGGSLLTYLRK------------NSNGLTTRQQMGMCRDAAA----GMRYLE 1177
            ...||.|:|||::..|:|..|||.            |...:..|.:.   .:.||    ||.|||
 Worm  1401 STVQPAMVVMEMMDLGNLRDYLRSKREDEVFNETDCNFFDIIPRDKF---HEWAAQICDGMAYLE 1462

  Fly  1178 SKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSL 1240
            |....|||||||||:::.:.:|||.||||:|:  ..:|....|.:.:||:|.:||:|..||:.|.
 Worm  1463 SLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSK 1527

  Fly  1241 CDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYR-MPTPKSTPEEMYRLMLQCWAADAESR 1304
            .||||:|::::|:.:.|..||.|::|......|....: :..|:......|::|..||......|
 Worm  1528 SDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDR 1592

  Fly  1305 PHFDEIYNVVDA 1316
            |.|.::.:::.|
 Worm  1593 PTFLQLVHLLAA 1604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	19/100 (19%)
		SH2_Fps_family	953..1039	CDD:198224	15/92 (16%)
		PTKc_Fes_like	1067..1315	CDD:270637	87/273 (32%)
daf-2	NP_001299916.1	Recep_L_domain	180..305	CDD:460032
		Furin-like	360..490	CDD:395614	11/34 (32%)
		Recep_L_domain	512..627	CDD:460032	24/151 (16%)
		FN3	776..>832	CDD:238020	14/73 (19%)
		FN3	1169..1255	CDD:238020	22/116 (19%)
		PTKc_InsR_like	1321..1604	CDD:173625	95/285 (33%)