DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and R05H5.4

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_496201.1	Gene:	R05H5.4 / 174581	WormBaseID:	WBGene00011039	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	123/373 - (32%)
Similarity:	206/373 - (55%)	Gaps:	15/373 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 WFHGVLPREEVVRLLNNDGDFLV--RETIRNEESQIVLSV-CWNGHKHFIVQTTGEGNFRFEGPP 1021
            :|||.|...:..:||.|:|||:|  ::.:...:.|:.|:| ...|.:.:.::.|.: ..:..|..
Worm    16 YFHGALMNIDADQLLVNEGDFMVTMKKQLDINKLQLFLAVRLKKGIRRYEIKRTSK-TAKIGGKT 79

  Fly  1022 FASIQELIMHQYHSELPVTVK-SGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKST 1085
            ..:|.:|| :...:: |:.:: ...:|:|.:.:.:::|.:.||:..::||.|.:|.||:.||..|
Worm    80 SQNIVKLI-NMLKAD-PIEIRGEKVVLKRAIPKGKFQLMHKDVIFQKKIGAGAYGTVYRGKLVKT 142

  Fly  1086 KLDVAVKTCRMTLPDEQ-KRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTY 1149
            ...:|||.......||. ..:.::|.|:::.||||||||..|..:...|.::|:|...||::...
Worm   143 DEVIAVKKLDPEGADEDGLAEMMKEARVMQLYDHPNIVKFHGFILDDLPYLLVLEYCNGGAVEDR 207

  Fly  1150 LRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHS--VKISDFGMSREEEE 1212
            ||.....:....::.....||.||.||..|||||||:|:||||:   |.  ||::||||.|.:..
Worm   208 LRDKGEKIKVPTRVKYTYMAACGMDYLHKKNCIHRDIASRNCLI---HKGVVKMADFGMCRAQSV 269

  Fly  1213 YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIF-SKGDTPYSGMTNSRARERIDTG 1276
            |.| |..|...::|.|||..:.|:.....||:::||:|||.| :...:||..|..::.:.:...|
Worm   270 YKV-DLKKPCNIRWLAPEVWDNGETRFNTDVYAFGIMMWEFFETPFKSPYVEMKAAQVKRKTRAG 333

  Fly  1277 YRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDNS 1324
            ||:|.|.|.|..|..:|.:||..|||.||..:|:...::....:.:||
Worm   334 YRLPPPPSMPSRMVEIMSECWQVDAEKRPTAEELKEKLEEFKKKTENS 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	20/81 (25%)
		TyrKc	1063..1311	CDD:197581	96/251 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	95/251 (38%)
R05H5.4	NP_496201.1	SH2_Fps_family	9..97	CDD:198224	21/83 (25%)
		TyrKc	120..363	CDD:197581	94/246 (38%)
		PKc_like	124..363	CDD:304357	93/242 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810