Protein Alignment FER and cam-1

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_001021907.1
• Gene: cam-1 / 174473
• WormBaseID: WBGene00000289
• Length: 928
• Species: Caenorhabditis elegans
• Alignment Length: 1016
• Identity: 216/1016 - (21%)
• Similarity: 368/1016 - (36%)
• Gaps: 280/1016 - (27%)

  Fly   406 DDDLTLEQNFIEN-GYNNEQQRSNSTSS-PGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPAT 468
            ||||.:|....|. .|.|......||.. |.:.:.::|..    .|...|....||.::...|..
 Worm     7 DDDLVIEPADDEGLHYGNASMEGTSTGQRPYIRLTSQLRN----ATKSSGDEVRFKCEALGTPPL 67

  Fly   469 ---------PMTRSRQGRFNKLQPRSQ-SLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYLG 523
                     |:.::::.:....:..|: .:..|.|:..|      .|:.|.::   .||||:
 Worm    68 KFIWLKNNGPVEKTKRVKIRDKENSSRLVITQLDVLDSG------YYQCIVSN---PAASVN--- 120

  Fly   524 EEIATSS----TNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHI---- 580
                |:|    .|.||..:|.:.:.|                            :.:..||
 Worm   121 ----TTSVLRVNNVPDAVKLSQKKGS----------------------------HHSTKHIAFDE 153

  Fly   581 YADLEL--------DKKKDTSPSPE-CKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRV 636
            |.|.|:        ::..|....|: ..|....|          ....:..:|....|:.:..:.
 Worm   154 YEDYEMMDRGRLPDEEDADLYRVPDSAAGSNYAP----------VAVSERWLDGIKYRVGDCVQY 208

  Fly   637 LDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSF 701
            ..:..::.|.....:...||.||.:        |.|    |:..::....:...|...|.|.||
 Worm   209 RGEACRQYLSNKFVMMTNESREEMY--------DID----RNLRAAMLFINGAPTISQKCRQLS- 260

  Fly   702 SQKSISNIFSNLKEFSKSPLVRMGKNH---ILNEEQDAKRTQPSQH---------------HHSS 748
            ...:..:::...:..|.:.:|.:.|:.   |.|:|..::....:||               ..||
 Worm   261 QAVACHHMYKVCESDSNNQIVSICKHDCDVIQNDECPSELALAAQHELVGDTPKALFPLCSRLSS 325

  Fly   749 GSDC-PTNSSSSSSNNNNNNKNTSSNSNH-----SASQSTIITSTITTTITTTTTTTPSKENSRL 807
            .|:| |..|::..|     :.....|..|     ..:..|....|:..| ::.....|..:::..
 Worm   326 TSNCIPVMSTALQS-----SPVAEVNRGHLTHWCYVNSGTQYEGTVAQT-SSGKQCAPWIDSTSR 384

  Fly   808 KFKV---PKIQKKSKAIRNTFRSKLLNFQLKRSKP-CKQCTKRRRIHPSKSVFDFAKEFEVEQPA 868
            .|.|   |::.......||...        |:|:| |                       ..:|.
 Worm   385 DFNVHRFPELMNSKNYCRNPGG--------KKSRPWC-----------------------YSKPM 418

  Fly   869 GSAADEQFCNCP--PAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSA----- 926
            |   .|::|:.|  |:...|.....::.|       |:.|.:.|:.....|:.:.....|
 Worm   419 G---QEEYCDVPQCPSDMYPHLNDKKVEG-------STKGGVSESVTALWDSLDPTMQVALVGGG 473

  Fly   927 ----------------------SDDVLSMKDHCYCVPSLAASISLS--------TNRPLYEEEWF 961
                                  |........||...||:..|.:.|        |:.|:...
 Worm   474 VFFSLLLLLLFCCACCCRAKKKSQKTRHQNAHCSSAPSVINSAANSAYYRKLNGTSTPIMGR--- 535

  Fly   962 HGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQ 1026
              |.|..|:..||.:                              .|..|.       ||:...|
 Worm   536 --VPPHVEMTSLLPS------------------------------AQHLGP-------PPYPMDQ 561

  Fly  1027 ELIM-HQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKS-----T 1085
            .|.. .::.|:.|:...|..:         :|::...:.:.|:||.|.||.|:.....|     .
 Worm   562 HLQQARRFPSQEPIDDNSYKV---------FEITPSQLSVREKIGEGQFGVVHSGIYTSGLFAPE 617

  Fly  1086 KLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYL 1150
            .:.||||.||....:.::.:..||.|.:..:||||::||||:|.....::.|.|.::.|.|...|
 Worm   618 PMAVAVKKCRHDATNAERAQLEQEIRAVATFDHPNVIKLIGVCYMDNSLLAVFEYMVHGDLHELL 682

  Fly  1151 R-------KNSNGLT--TRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGM 1206
            :       .:..|:|  ..:.:.:....|.||.||.|.:.:|||||.|||||....::||:|||:
 Worm   683 KVRVPPADHDMGGITEANAEFLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGL 747

  Fly  1207 SREE--EEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRA 1269
            .|..  .:|........:||:|.:.||:..|:::...||||:|:.:|||:|.|..||.|.:|.:.
 Worm   748 MRTSYGSDYYKMLHRSWMPVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQV 812

  Fly  1270 RERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            .|.:...:.:..|.:.|..:|.||::||..:.|.||.|.||
 Worm   813 IELVANRHLLECPHNCPTNIYSLMVECWHENIERRPTFSEI 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	13/86 (15%)
		TyrKc	1063..1311	CDD:197581	90/264 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	90/260 (35%)
cam-1	NP_001021907.1	I-set	39..127	CDD:254352	19/107 (18%)
		Ig	55..122	CDD:143165	14/82 (17%)
		CRD_TK_ROR_like	203..335	CDD:143568	26/144 (18%)
		KR	352..431	CDD:214527	18/113 (16%)
		STYKc	590..857	CDD:214568	90/264 (34%)
		PTKc	594..858	CDD:270623	90/260 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910