DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and let-23

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001300607.1	Gene:	let-23 / 174462	WormBaseID:	WBGene00002299	Length:	1335	Species:	Caenorhabditis elegans

Alignment Length:	1112	Identity:	228/1112 - (20%)
Similarity:	383/1112 - (34%)	Gaps:	376/1112 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 ELEG-AVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSN---KDSLCRQ--------- 368
            ||:| .:..|..:  |:..|..|...........||::........   ::.:|.:
Worm   298 ELDGICIETCPSR--KIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYD 360

  Fly   369 -SKDLNAL-RCQEKQKQKLVDMIKCALNEV-----GCEELPSGCDDDLTLEQNFIENGYNNEQQR 426
             :||:... :|:.....|:..:.....||.     |||::    |..|     .||:.:..||.:
Worm   361 ATKDVRECEKCRSSSCPKICTVDGHLTNETLKNLEGCEQI----DGHL-----IIEHAFTYEQLK 416

  Fly   427 SNSTSSPGLGIMNE---LMRRGGV-------LTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKL 481
            ...|    :.|::|   ::::...       |.::.||..|..|.:       :...:.....:|
Worm   417 VLET----VKIVSEYITIVQQNFYDLKFLKNLQIIEGRKLHNVRWA-------LAIYQCDDLEEL 470

  Fly   482 QPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSM 546
                 ||.||.:|:.|      ....:.||||...:.:.:.....:....|.|.|. :...:.|.
Worm   471 -----SLNSLKLIKTG------AVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLA-IAENRDSK 523

  Fly   547 LCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHIYADLELDKK----KDTSPSPECKG------- 600
            ||  |.|:.|                         .|...:|:    |:.....|||.
Worm   524 LC--ETEQRV-------------------------CDKNCNKRGCWGKEPEDCLECKTWKSVGTC 561

  Fly   601 -EQIQPK---KEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEE-- 659
             |:...|   :.|..::..:.:|:......|..:|    .|..|.| ||..||..|.:|...:
Worm   562 VEKCDTKGFLRNQTSMKCERCSPECETCNGLGELD----CLTCRHK-TLYNSDFGNRMECVHDCP 621

  Fly   660 -NHIQTRKLAKD-------------PDS--------QTK-------------RSSSSSSEC---- 685
             :|..|:|...:             |||        |.|             :||..::.|
Worm   622 VSHFPTQKNVCEKCHPTCYDNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVEND 686

  Fly   686 -----RSSKDT-----SHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNE------EQ 734
                 .|:.||     :|.:|.|:|.  |:.|:               .|:|.:.|:      |.
Worm   687 LPNYYISTYDTEGVIETHCEKCSISC--KTCSS---------------AGRNVVQNKCVCKHVEY 734

  Fly   735 DAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTT 799
                 ||:.........||.||......||    ......:|...|
Worm   735 -----QPNPSERICMDQCPVNSFMVPDTNN----TVCKKCHHECDQ------------------- 771

  Fly   800 PSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLK--RSKPCKQCTKRRRIHPSKSVFDFAKEF 862
                                           |:...  :|..|::|                |.|
Worm   772 -------------------------------NYHCANGQSTGCQKC----------------KNF 789

  Fly   863 EVEQPAGSAADEQFC--NCPPAGQKPVKPSVQISGHKDHPFES-SSGELDENSDRDIDNDEEEED 924
            .|.:  |..|.   |  .||                |:.||.: ::||.   .|.||.:.:.
Worm   790 TVFK--GDIAQ---CVSECP----------------KNLPFSNPANGEC---LDYDIASRQR--- 827

  Fly   925 SASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNE 989
                     |.....:.|:....::.                             ||
Worm   828 ---------KTRMVIIGSVLFGFAVM-----------------------------FL-------- 846

  Fly   990 ESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRE 1054
               .:|.|.|.      .|..|:.         ..|.|::      ::|......|.:|..:.|.
Worm   847 ---FILLVYWR------CQRIGKK---------LKIAEMV------DMPELTPIDASVRPNMSRI 887

  Fly  1055 RWELSND-DVVLLERIGRGNFGDV-----YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRIL 1113
            ....|:: ...|.:::|.|.||.|     |..:.|:.|:.||:|.  ......|..:.|:|...:
Worm   888 CLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKV--FQTDQSQTDEMLEEATNM 950

  Fly  1114 KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLES 1178
            .:..|.|::|:||.|:....:.||......|:|..:|:.:...|..|:|:..|...|:||:|||.
Worm   951 FRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEK 1015

  Fly  1179 KNCIHRDLAARNCLVDLEHSVKISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALNFGKYTS 1239
            :..:|||||.||.||...:.|:|:|||:|:    :.:...:..|  ::.:||.|.|..:...||.
Worm  1016 QRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSG--KVAIKWLAIEIFSKHCYTH 1078

  Fly  1240 LCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESR 1304
            ..|||::|:..|||.:.|.:||.||:.......:..|.|:..|.:..:::|:.:|:||.||.:||
Worm  1079 ASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSR 1143

  Fly  1305 PHFDEIY 1311
            |.|:.:|
Worm  1144 PGFEILY 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	9/85 (11%)
		TyrKc	1063..1311	CDD:197581	83/256 (32%)
		PTKc_Fes_like	1067..1315	CDD:270637	83/254 (33%)
let-23	NP_001300607.1	Recep_L_domain	77..205	CDD:279382
		Furin-like	229..378	CDD:279142	13/81 (16%)
		FU	274..>308	CDD:238021	3/9 (33%)
		Recep_L_domain	396..503	CDD:279382	28/137 (20%)
		GF_recep_IV	531..652	CDD:291509	28/150 (19%)
		FU	532..580	CDD:238021	9/47 (19%)
		FU	578..625	CDD:214589	12/51 (24%)
		FU	759..806	CDD:214589	15/137 (11%)
		PKc_like	885..1164	CDD:304357	86/270 (32%)
		TyrKc	898..1153	CDD:197581	84/257 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910