DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and vab-1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_494807.1	Gene:	vab-1 / 173794	WormBaseID:	WBGene00006868	Length:	1117	Species:	Caenorhabditis elegans

Alignment Length:	1198	Identity:	256/1198 - (21%)
Similarity:	400/1198 - (33%)	Gaps:	470/1198 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 INP---TEEYGEFTEKYKTS-PTTPLLFQFDETLIQDIP-----GKL--QSSTLTVDNLTVD--- 309
            :||   .|.:..:.:::||| |.:..:.:  |...:||.     |:|  .:|.:|.:.|.::
Worm   122 LNPKSCKETFSVYLKQFKTSRPGSTKIEK--ERFSEDIDNWKNIGRLARSNSNMTTETLGMEIDS 184

  Fly   310 ---WLRNRLQELEGA----------VRDCQE---------------KQMKMIEHVNGGSPVANGS 346
               .:|...:| :|.          .|.|.|               |:..|:.        .|||
Worm   185 DTKTIRIAFEE-QGICLSLLNVKIYYRICDEFTDQLVYFRPQVTGPKETDMVR--------MNGS 240

  Fly   347 IISNGS-------------NTSNGIQSNKDSLC----RQSKDLNALRCQ----EKQKQKLVDMIK 390
            .|.|.|             :|.:||:::.:.:|    .|..|.|..||:    ...|.|...:.|
Worm   241 CIPNASKKIPGVDLIGLCMSTGSGIKTSGECVCDSGYSQIADSNGARCESCPTNTYKPKGQSLCK 305

  Fly   391 -CALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRGR 454
             |..|.:. .|..|.|.         ..|||                              .|..
Worm   306 SCPSNSIS-SEAASSCR---------CLNGY------------------------------FRAE 330

  Fly   455 GRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASV 519
            ........|..|:.|:         ||.  :.::.:.|.....|.||.....|          .:
Worm   331 DELISMPCTQPPSRPI---------KLV--ANAITATSTRLSWNEPSSLGGRP----------EI 374

  Fly   520 HYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHIYADL 584
            .|                       .:.|.|..|...|:.:|.
Worm   375 WY-----------------------EVKCSGRGECGTVVMTPG---------------------- 394

  Fly   585 ELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAP----------QNSIDAHLDRIDELNRVLDD 639
              |||..|.                 .::||...|          :|.:.|......|.|.|:|
Worm   395 --DKKLSTR-----------------SVQINGLRPSSDYTFLVFAKNKVSAQFPEFSEKNAVID- 439

  Fly   640 RLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQK 704
              .||....:||..:     :|::.                         |.|.|...::::
Worm   440 --IRTRSEEEDVPPV-----SHLRV-------------------------DASQSDGITIAW--- 469

  Fly   705 SISNIFSNLKEFS---KSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNN 766
            |:|:  |::.:|.   :..:|:             |||..::|
Worm   470 SVSD--SDVSDFEVEVRPAIVK-------------KRTFETRH---------------------- 497

  Fly   767 NKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFR-SKLL 830
                             :..|.||.|.....|.       .:|:|        .||:..| |:.:
Worm   498 -----------------VNMTYTTFIGLNPETV-------YQFRV--------RIRDDLRWSQPI 530

  Fly   831 NFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCN----------------- 878
            ::||.|.....         ||.:        |||       :.||.|
Worm   531 SYQLGRGLMSS---------PSSN--------EVE-------ESQFLNQTGSALLIIIALILIVI 571

  Fly   879 ----CPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYC 939
                |....||..|...|:                  ||.|: .|..::||.:.|..:...|.:.
Worm   572 AVALCMIVVQKKSKNRKQM------------------SDLDV-LDTYKQDSMTPDYHTTSRHHHH 617

  Fly   940 VPSLAASI------SLSTNRPLYEE---------EWFHGVLPREEVVRLLNNDGDF--LVRETIR 987
            ..:|.|::      :...|.||...         .::.||.|         |.|.:  .|..|..
Worm   618 QGNLPATLHEQLRSTTKLNAPLIPSFGSPISQPPPYYGGVHP---------NSGKYKTYVDPTTY 673

  Fly   988 NEESQIVLSVCW--NGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRP 1050
            .:..|.::...:  :.:..||.|..|.|.|.                       .|..|.:.:..
Worm   674 EDPYQALIEFTFDISPNDVFITQVIGGGEFG-----------------------DVCLGGLSKNS 715

  Fly  1051 VCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQ 1115
            ....:|.:||      ..:|||..|..|:::...|   ||:||.:.....:.|.:||.|..|:.|
Worm   716 PAAAKWSVSN------TTMGRGGGGGGYESEPYET---VAIKTLKSGSSAKAKAEFLTEATIMGQ 771

  Fly  1116 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMG----------MCRDAA 1170
            :.|||:::|||:....:|:|||.|.:..|||..:||..       .|.|          |....|
Worm   772 FSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNT-------DQRGEKVHWEKITEMLYGIA 829

  Fly  1171 AGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--------EEEEYIVSDGMKQIPVKWT 1227
            :||:||.....:||||||||.|:|:|...||:|||:||        .|.||..:.|  :|||:||
Worm   830 SGMKYLTDMGYVHRDLAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEYTTNGG--KIPVRWT 892

  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRL 1292
            ||||:...|:|...||||:|:::||:.|.|:.||...||.:....:..|||:|.|...|..:||:
Worm   893 APEAITHRKFTPSSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIGYRLPPPMDCPMGLYRI 957

  Fly  1293 MLQCWAADAESRPHFDEIYNVVDALILR 1320
            ...||..:...||.|.::.......||:
Worm   958 AQWCWKMERHERPTFTQLLATFHKYILQ 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	16/98 (16%)
		TyrKc	1063..1311	CDD:197581	99/265 (37%)
		PTKc_Fes_like	1067..1315	CDD:270637	99/265 (37%)
vab-1	NP_494807.1	EphR_LBD	32..211	CDD:198439	18/91 (20%)
		FN3	342..423	CDD:238020	22/165 (13%)
		FN3	450..531	CDD:238020	24/182 (13%)
		EphA2_TM	<642..687	CDD:291255	8/53 (15%)
		PTKc_EphR	687..983	CDD:270629	110/336 (33%)
		STYKc	692..979	CDD:214568	110/327 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910