DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Met

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_032617.2	Gene:	Met / 17295	MGIID:	96969	Length:	1379	Species:	Mus musculus

Alignment Length:	1180	Identity:	255/1180 - (21%)
Similarity:	420/1180 - (35%)	Gaps:	368/1180 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 TEKYKTSPTTPL----LF--QFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRLQELEGA-VRDCQ 326
            :::|:|..||.|    ||  :.::.|:..|      ||....:||:    ..|...||. ::...
Mouse   412 SDEYRTEFTTALQRVDLFMGRLNQVLLTSI------STFIKGDLTI----ANLGTSEGRFMQVVL 466

  Fly   327 EKQMKMIEHVN---GGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQEKQKQKLVDM 388
            .:...:..|||   ...||:...|:.:.|| .||.     :|....|.:.
Mouse   467 SRTAHLTPHVNFLLDSHPVSPEVIVEHPSN-QNGY-----TLVVTGKKIT--------------- 510

  Fly   389 IKCALNEVGCEELPSGCDDDLTLEQNFIENGY-NNEQQRSNS--------------------TSS 432
             |..||.:||....| |...|:... ||:.|: :|:..|.:.                    ||:
Mouse   511 -KIPLNGLGCGHFQS-CSQCLSAPY-FIQCGWCHNQCVRFDECPSGTWTQEICLPAVYKVFPTSA 572

  Fly   433 PGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDG 497
            |        :..|.|||:. |....|::.                 ||...|.      :.:..|
Mouse   573 P--------LEGGTVLTIC-GWDFGFRKN-----------------NKFDLRK------TKVLLG 605

  Fly   498 NGPSPARYEPITNHRLR----QAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVL 558
            |..........|.:.|:    .|.|.|:....|.::|.        ..||.|....   .:||:.
Mouse   606 NESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIISNSR--------ETTQYSAFSY---VDPVIT 659

  Fly   559 A-SP-------APLTQLTAAVLTNTNNNHIYADLELDKKKDTSPS-PECKGEQIQPKKEQIRIEI 614
            : ||       ..|..||...|.:.|:.||....:....|..|.| .||. ...|...::..:::
Mouse   660 SISPRYGPQAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECY-TPAQTTSDEFPVKL 723

  Fly   615 NQTAPQNSIDAHLDRIDELNR------VLDDRLKRTLQPSDD--------------VNAIESAEE 659
                          :||..||      ..:|.:...:.|:..              :|:: |..:
Mouse   724 --------------KIDLANRETSSFSYREDPVVYEIHPTKSFISGGSTITGIGKTLNSV-SLPK 773

  Fly   660 NHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKS-----ISNIFSN------- 712
            ..|...::..:.....:..|:|...|.:   |...|:..|....|:     :..|.|.
Mouse   774 LVIDVHEVGVNYTVACQHRSNSEIICCT---TPSLKQLGLQLPLKTKAFFLLDGILSKHFDLTYV 835

  Fly   713 ----LKEFSKSPLVRMGKNHIL-----NEEQDAKRTQ---------PSQHHHSSGSDCPTNSSSS 759
                .:.|.|..::.:|..:::     |.:.:|.:.:         .|.|.||....|...|...
Mouse   836 HNPVFEPFEKPVMISIGNENVVEIKGNNIDPEAVKGEVLKVGNQSCESLHWHSGAVLCTVPSDLL 900

  Fly   760 SSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKI---------- 814
            ..|         |..|....|:      :::|:.......|.:..:.|......|
Mouse   901 KLN---------SELNIEWKQA------VSSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLLSGL 950

  Fly   815 ---QKKSKAIRNTFRSKLLNFQLKRSKP-CKQCTKRRRIHP-----SKSVFDFAKEFEVEQPAGS 870
               .:|.|  .....|:|:.:..:...| ..:....|.:.|     |....|:...|
Mouse   951 FLWMRKRK--HKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATF-------- 1005

  Fly   871 AADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKD 935
             .::||   |.:.|......||      :|....|..| .:.|.||          |..:|....
Mouse  1006 -PEDQF---PNSSQNGACRQVQ------YPLTDLSPIL-TSGDSDI----------SSPLLQNTV 1049

  Fly   936 HCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWN 1000
            |          |.||...|                                     ::|.:|
Mouse  1050 H----------IDLSALNP-------------------------------------ELVQAV--- 1064

  Fly  1001 GHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVL 1065
              :|.::           ||     ..||:|                                 .
Mouse  1065 --QHVVI-----------GP-----SSLIVH---------------------------------F 1078

  Fly  1066 LERIGRGNFGDVYKAKL---KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGI 1127
            .|.||||:||.||...|   ...|:..|||:.......|:..:||.||.|:|.:.|||::.|:||
Mouse  1079 NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGI 1143

  Fly  1128 CVQKQ--PIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARN 1190
            |::.:  | ::|:..:..|.|..::|..::..|.:..:|.....|.||:||.||..:||||||||
Mouse  1144 CLRSEGSP-LVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARN 1207

  Fly  1191 CLVDLEHSVKISDFGMSR---EEEEYIVSD--GMKQIPVKWTAPEALNFGKYTSLCDVWSYGILM 1250
            |::|.:.:||::|||::|   ::|.|.|.:  |.| :||||.|.|:|...|:|:..||||:|:|:
Mouse  1208 CMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAK-LPVKWMALESLQTQKFTTKSDVWSFGVLL 1271

  Fly  1251 WEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVD 1315
            ||:.::|..||..:........:..|.|:..|:..|:.:|.:||:||...||.||.|.|:.:.:.
Mouse  1272 WELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRIS 1336

  Fly  1316 ALILRLDNSH 1325
            ::.......|
Mouse  1337 SIFSTFIGEH 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	9/85 (11%)
		TyrKc	1063..1311	CDD:197581	98/257 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	98/257 (38%)
Met	NP_032617.2	Sema	25..515	CDD:387663	29/134 (22%)
		PSI	518..560	CDD:214655	10/43 (23%)
		IPT_plexin_repeat1	562..655	CDD:238585	24/135 (18%)
		IPT_plexin_repeat2	656..739	CDD:238584	21/97 (22%)
		IPT	741..836	CDD:387656	13/98 (13%)
		IPT_PCSR	838..917	CDD:238337	15/93 (16%)
		PTKc_Met_Ron	1080..1341	CDD:270649	98/262 (37%)
		Interaction with RANBP9. /evidence=ECO:0000250	1210..1379		48/138 (35%)
		Interaction with MUC20. /evidence=ECO:0000250	1318..1357		8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900