DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and kin-32

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_740841.1	Gene:	kin-32 / 172135	WormBaseID:	WBGene00002213	Length:	867	Species:	Caenorhabditis elegans

Alignment Length:	361	Identity:	119/361 - (32%)
Similarity:	187/361 - (51%)	Gaps:	33/361 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   968 EEVVRLLNNDG---DFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELI 1029
            |:.:..||..|   ..|:  |:..||....|:...:|::  ::....:..|:.:|  ....:.|.
Worm   284 EKTLMQLNLSGAAKPVLI--TLSTEELSQSLAHLLDGYQ--MLYNQRDSVFKLKG--IERCETLT 342

  Fly  1030 MHQ--YHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKL----KSTKLD 1088
            ||:  ...:.|..:.|...|||.:           :.|.|.||.|.||:||||..    |..::.
Worm   343 MHEATIRPKTPNNIDSNIRLRREL-----------ITLKELIGGGQFGNVYKAVYHDLEKDERIA 396

  Fly  1089 VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN 1153
            ||||.|:........:..|||..:::.:.|.||::|||:||. ||:.:|:||...|.|..||::.
Worm   397 VAVKVCKTDAEPADTQLILQESSLMRNFRHSNIIQLIGVCVD-QPMWLVLELAPKGELREYLQQE 460

  Fly  1154 SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE---EEEYIV 1215
            .:.|..|.....|......:.||.|...:|||:||||.||.....||::|||:||.   :..|..
Worm   461 KDWLPLRILTLFCSQICDSLVYLHSTRFVHRDIAARNILVCSPQCVKLADFGLSRALDYDAVYTA 525

  Fly  1216 SDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMP 1280
            |.|  ::|:||.|||::|:.:::...|||.:|:.||||||.|..|::|:|||.....|:.|.|.|
Worm   526 SRG--KLPIKWLAPESVNYRQFSMASDVWMFGVCMWEIFSLGVKPWAGVTNSDVIMHIEQGSRPP 588

  Fly  1281 TPKSTPEEMYR-LMLQCWAADAESRPHFDEIYNVVD 1315
            .|:..|..:|. :..:.||.:...||..|:||.:::
Worm   589 CPEKCPTALYNFIRSKMWAIEPHKRPTVDQIYAIIE 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/75 (20%)
		TyrKc	1063..1311	CDD:197581	97/255 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	98/255 (38%)
kin-32	NP_740841.1	B41	5..230	CDD:214604
		FERM_C_FAK1	226..336	CDD:270011	12/57 (21%)
		PKc_like	360..631	CDD:304357	102/279 (37%)
		STYKc	367..623	CDD:214568	99/258 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910