DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and spe-8

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_490680.1	Gene:	spe-8 / 171606	WormBaseID:	WBGene00004962	Length:	512	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	149/530 - (28%)
Similarity:	231/530 - (43%)	Gaps:	113/530 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   758 SSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIR 822
            |.||..:...::|.|..:..            ||.|.:..|.|..:..|           :.|:.
Worm     3 SKSSEGDLQPEDTQSREDKE------------TTATYSEDTKPETQKER-----------NAALD 44

  Fly   823 NTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPV 887
            |..::.:   ||                             |.||.........|..||. ..|.
Worm    45 NLAKTPI---QL-----------------------------VVQPTPLTPAITPCEAPPP-PPPP 76

  Fly   888 KPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTN 952
            |||                 .|.|:.:.:...::..:..||:|..::::.             .|
Worm    77 KPS-----------------SDNNNSKRLKVKDQLIEVPSDEVGRVENNI-------------DN 111

  Fly   953 RPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHK-HFIVQTTGEGNFR 1016
            .|.|     ||.:.|.|...:|:|.||||:|.|...:....|:|:.|.... |.:|:.|......
Worm   112 FPFY-----HGFMGRNECEAMLSNHGDFLIRMTEIGKRVAYVISIKWKYQNIHVLVKRTKTKKLY 171

  Fly  1017 F-EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKA 1080
            : :...|.||.|||  .||......:..|..|...:.|..|:|:|:.|.|.:::|.|.||:|:|.
Worm   172 WTKKYAFKSICELI--AYHKRNHKPIYEGMTLICGLARHGWQLNNEQVTLNKKLGEGQFGEVHKG 234

  Fly  1081 KLKST----KLDVAVKTCRMT-LPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMEL 1140
            .||::    .:.|||||.... |...:|..||:|..::....|||::|..|:|..|:|||||||.
Worm   235 SLKTSVFAAPVTVAVKTLHQNHLSANEKILFLREANVMLTLSHPNVIKFYGVCTMKEPIMIVMEF 299

  Fly  1141 VLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFG 1205
            ..|.||...|......::...::.....||.|:.||..|..||||:||||||::.:..:||||||
Worm   300 CDGKSLEDALLSKEEKVSAEDKILYLFHAACGIDYLHGKQVIHRDIAARNCLLNSKKILKISDFG 364

  Fly  1206 MSREEEEYIVSDGMKQ-----IPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYS--G 1263
            :|      :....:|:     :|||:.|||.|..|.|::..|::|||.||:|:::.|.||:.  |
Worm   365 LS------VKGVAIKERKGGCLPVKYMAPETLKKGLYSTASDIYSYGALMYEVYTDGKTPFETCG 423

  Fly  1264 MTNSRARERI 1273
            :..:..|:.|
Worm   424 LRGNELRKAI 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/87 (32%)
		TyrKc	1063..1311	CDD:197581	84/223 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	82/219 (37%)
spe-8	NP_490680.1	SH2_Fps_family	109..195	CDD:198224	29/105 (28%)
		TyrKc	217..475	CDD:197581	84/223 (38%)
		PTKc	221..476	CDD:270623	82/219 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770