DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Lyn

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001104566.1	Gene:	Lyn / 17096	MGIID:	96892	Length:	512	Species:	Mus musculus

Alignment Length:	411	Identity:	144/411 - (35%)
Similarity:	215/411 - (52%)	Gaps:	59/411 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   948 SLSTNR-------------PLYEEEWFHGVLPREEVVRLL----NNDGDFLVR--ETIRNEESQI 993
            |||:.|             .|..||||...:.|::..|.|    |:.|.||:|  ||::...|
Mouse   104 SLSSKREGFIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFS-- 166

  Fly   994 VLSV----CWNGH--KHFIVQTTGEGNFRFEGP--PFASIQELIMHQYHSELPVTVKSGAILRR- 1049
             |||    ..:|.  ||:.:::...|.: :..|  .|..|.::|.| |..:      |..:.||
Mouse   167 -LSVRDYDPMHGDVIKHYKIRSLDNGGY-YISPRITFPCISDMIKH-YQKQ------SDGLCRRL 222

  Fly  1050 -----------PVCRERWELSNDDVVLLERIGRGNFGDVYKAKL-KSTKLDVAVKTCRMTLPDEQ 1102
                       |..::.||:..:.:.|::::|.|.||:|:.... .|||  |||||.:......|
Mouse   223 EKACISPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTK--VAVKTLKPGTMSVQ 285

  Fly  1103 KRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG-LTTRQQMGMC 1166
              .||:|..::|...|..:|:|..:..:::||.|:.|.:..||||.:|:.:..| :...:.:...
Mouse   286 --AFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFS 348

  Fly  1167 RDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAP 1229
            ...|.||.|:|.||.|||||.|.|.||......||:|||::|  |:.||...:|.| .|:|||||
Mouse   349 AQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAK-FPIKWTAP 412

  Fly  1230 EALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLML 1294
            ||:|||.:|...||||:|||::||.:.|..||.|.||:.....:..|||||..::.|:|:|.:|.
Mouse   413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRMENCPDELYDIMK 477

  Fly  1295 QCWAADAESRPHFDEIYNVVD 1315
            .||...||.||.||.:.:|:|
Mouse   478 MCWKEKAEERPTFDYLQSVLD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/112 (27%)
		TyrKc	1063..1311	CDD:197581	103/251 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/251 (41%)
Lyn	NP_001104566.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		SH3_Lyn	67..122	CDD:212937	4/17 (24%)
		SH2_Src_Lyn	125..225	CDD:198227	31/110 (28%)
		PTKc_Lyn	239..510	CDD:270657	107/265 (40%)
		Pkinase_Tyr	247..497	CDD:285015	103/254 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910