DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Limk1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_036020724.1	Gene:	Limk1 / 16885	MGIID:	104572	Length:	702	Species:	Mus musculus

Alignment Length:	350	Identity:	87/350 - (24%)
Similarity:	146/350 - (41%)	Gaps:	85/350 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1049 RPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRIL 1113
            |.|||........|::..|.:|:|.||...|...:.|. :|.|....:...:|.:|.||:|.:::
Mouse   325 RVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETG-EVMVMKELIRFDEETQRTFLKEVKVM 388

  Fly  1114 KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLES 1178
            :..:|||::|.||:..:.:.:..:.|.:.||:|...::...:.....|::...:|.|:||.||.|
Mouse   389 RCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHS 453

  Fly  1179 KNCIHRDLAARNCLV---------------------------------DLE-------------- 1196
            .|.|||||.:.||||                                 :||
Mouse   454 MNIIHRDLNSHNCLVREPSQTPPEVAQATQAAATTATVCGQGHLGRLLELETWQRHVRGGQEDKR 518

  Fly  1197 --------HSVKISDFGMSR------EEEEYIVS----DGMKQIPV----KWTAPEALNFGKYTS 1239
                    .:|.::|||::|      .:.|.:.|    |..|:..|    .|.|||.:|...|..
Mouse   519 QSAPSLQNRNVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDE 583

  Fly  1240 LCDVWSYGILMWEIFSK--GDTPYSGMTNSRARERIDTGYRMP------TPKSTPEEMYRLMLQC 1296
            ..||:|:||::.||..:  .|..|...|       :|.|..:.      .|.:.|...:.:.::|
Mouse   584 KVDVFSFGIVLCEIIGRVNADPDYLPRT-------MDFGLNVRGFLDRYCPPNCPPSFFPITVRC 641

  Fly  1297 WAADAESRPHFDEIYNVVDALILRL 1321
            ...|.|.||.|.::...::.|.:.|
Mouse   642 CDLDPEKRPSFVKLEQWLETLRMHL 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	80/324 (25%)
		PTKc_Fes_like	1067..1315	CDD:270637	80/324 (25%)
Limk1	XP_036020724.1	LIM1_LIMK1	5..77	CDD:188846
		LIM2_LIMK1	84..138	CDD:188848
		PDZ	165..255	CDD:395476
		STKc_LIMK1	345..666	CDD:271123	80/328 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910