DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Lck

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001155904.1	Gene:	Lck / 16818	MGIID:	96756	Length:	520	Species:	Mus musculus

Alignment Length:	478	Identity:	154/478 - (32%)
Similarity:	236/478 - (49%)	Gaps:	80/478 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   880 PPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLA 944
            |||  .|::.::.|:.|...|          :.|.|:..::.|:..    :|......:...||.
Mouse    67 PPA--SPLQDNLVIALHSYEP----------SHDGDLGFEKGEQLR----ILEQSGEWWKAQSLT 115

  Fly   945 ASIS-------LSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRE----------TIRN 988
            ....       ::....|..|.||...|.|::..|.|    |..|.||:||          ::|:
Mouse   116 TGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRD 180

  Fly   989 ---EESQIVLSVCWNGHKHFIVQTTGEGNFRFEGP--PFASIQELIMHQYHSELPVTVKSGAILR 1048
               .:.::|        ||:.::....|.| :..|  .|..:.:|:.|..::...:..|    |.
Mouse   181 FDQNQGEVV--------KHYKIRNLDNGGF-YISPRITFPGLHDLVRHYTNASDGLCTK----LS 232

  Fly  1049 RPVCR----------ERWELSNDDVVLLERIGRGNFGDVYKAKLKS-TKLDVAVKTCRM--TLPD 1100
            || |:          :.||:..:.:.|:||:|.|.||:|:...... ||  ||||:.:.  ..||
Mouse   233 RP-CQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTK--VAVKSLKQGSMSPD 294

  Fly  1101 EQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSN-GLTTRQQMG 1164
                .||.|..::||..||.:|:|..: |.::||.|:.|.:..|||:.:|:..|. .|...:.:.
Mouse   295 ----AFLAEANLMKQLQHPRLVRLYAV-VTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLD 354

  Fly  1165 MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWT 1227
            |....|.||.::|.:|.|||||.|.|.||....|.||:|||::|  |:.||...:|.| .|:|||
Mouse   355 MAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAK-FPIKWT 418

  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRL 1292
            ||||:|:|.:|...||||:|||:.||.:.|..||.||||....:.::.||||..|.:.|||:|.|
Mouse   419 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHL 483

  Fly  1293 MLQCWAADAESRPHFDEIYNVVD 1315
            |:.||....|.||.||.:.:|:|
Mouse   484 MMLCWKERPEDRPTFDYLRSVLD 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	24/104 (23%)
		TyrKc	1063..1311	CDD:197581	108/253 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	108/253 (43%)
Lck	NP_001155904.1	SH3_Lck	76..129	CDD:212938	9/66 (14%)
		SH2_Src_Lck	134..234	CDD:198225	25/112 (22%)
		PTKc_Lck_Blk	248..511	CDD:270652	112/267 (42%)
		Pkinase_Tyr	256..505	CDD:285015	108/256 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910