DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Jak2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001041642.1	Gene:	Jak2 / 16452	MGIID:	96629	Length:	1132	Species:	Mus musculus

Alignment Length:	418	Identity:	115/418 - (27%)
Similarity:	190/418 - (45%)	Gaps:	95/418 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   948 SLSTNRPL--YEE-------EWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHK 1003
            :|.:.|.|  ||:       :|       .|:..|:||..|:
Mouse   756 ALDSQRKLQFYEDKHQLPAPKW-------TELANLINNCMDY----------------------- 790

  Fly  1004 HFIVQTTGEGNFRFEGPPFASI----QELIMHQY----HSELPVTVKSGAI-------LRRPVCR 1053
                    |.:||   |.|.::    ..|....|    .:::...::.||:       .|.|...
Mouse   791 --------EPDFR---PAFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQF 844

  Fly  1054 ERWELSNDDVVLLERIGRGNFGDV----YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILK 1114
            |...|.     .|:::|:||||.|    |.....:|...||||..:.: .:|..|.|.:|..|||
Mouse   845 EERHLK-----FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS-TEEHLRDFEREIEILK 903

  Fly  1115 QYDHPNIVKLIGICVQ--KQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLE 1177
            ...|.||||..|:|..  ::.:.::||.:..|||..||:|:...:..::.:........||.||.
Mouse   904 SLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLG 968

  Fly  1178 SKNCIHRDLAARNCLVDLEHSVKISDFGMSR---EEEEYIVSDGMKQIPVKWTAPEALNFGKYTS 1239
            :|..||||||.||.||:.|:.|||.|||:::   :::||.......:.|:.|.|||:|...|::.
Mouse   969 TKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSV 1033

  Fly  1240 LCDVWSYGILMWEIFS---KGDTP---YSGMTNSRAR---------ERIDTGYRMPTPKSTPEEM 1289
            ..||||:|::::|:|:   |..:|   :..|..:..:         |.:.:..|:|.|:..|:|:
Mouse  1034 ASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEI 1098

  Fly  1290 YRLMLQCWAADAESRPHFDEIYNVVDAL 1317
            |.:|.:||..:...||.|.::...||.:
Mouse  1099 YVIMTECWNNNVSQRPSFRDLSLRVDQI 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	17/102 (17%)
		TyrKc	1063..1311	CDD:197581	89/271 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	88/271 (32%)
Jak2	NP_001041642.1	Interaction with cytokine/interferon/growth hormone receptors	1..239
		FERM_F1	39..134	CDD:408179
		FERM_F2	143..261	CDD:408177
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242
		PTK_Jak2_rpt1	545..806	CDD:270663	16/90 (18%)
		PTKc_Jak2_rpt2	844..1127	CDD:271107	93/289 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810