DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Itk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001268894.1	Gene:	Itk / 16428	MGIID:	96621	Length:	625	Species:	Mus musculus

Alignment Length:	679	Identity:	189/679 - (27%)
Similarity:	282/679 - (41%)	Gaps:	163/679 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   727 NHILNEEQDAKRTQPSQHHHSSGSDCP------TNSSSSSSNNNNNNKNTSSNSNHSASQS--TI 783
            |.||.|||..|::|  |...:|.|:..      |.:|.:...:.:..|.|...|...:...  .|
Mouse     3 NFILLEEQLIKKSQ--QKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEI 65

  Fly   784 ITSTITT------TITTTTTTTPSKENSRLKFKVPKIQKKSKAI---------RNTFRSKL-LNF 832
            :.|.|:.      ...|........:|..|....|..:.:.:.:         .|:..||. .||
Mouse    66 VKSDISIPCHYKYPFQTLVYLQVVHDNYLLYVFAPDCESRQRWVLTLKEETRNNNSLVSKYHPNF 130

  Fly   833 QLK-RSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPP------AGQKPVKPS 890
            .:. |.:.|.|                     :|:||        ..|.|      |.:||:.|:
Mouse   131 WMDGRWRCCSQ---------------------LEKPA--------VGCAPYDPSKNASKKPLPPT 166

  Fly   891 VQISGHKDHPFESSSGELDENSDRDIDNDEEE-----EDSASDDVLSMKDHC----YCVPS---- 942
                              .|::.|.....||.     .|..::|...:...|    |.:.|
Mouse   167 ------------------PEDNRRSFQEPEETLVIALYDYQTNDPQELALRCDEEYYLLDSSEIH 213

  Fly   943 ------------LAASISLSTNRP--LYEEEWFHGVLPREEVVRLL---NNDGDFLVRET----- 985
                        .|.|..|....|  |...||::..:.|::..:||   ..:|.|:||::
Mouse   214 WWRVQDKNGHEGYAPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTPGT 278

  Fly   986 ---------IRNEESQIVLSVCWNGHKHFIVQTTGEGNFRF---EGPPFASIQELIM-HQYHSEL 1037
                     |.:|...|         ||:.::.|.:...|:   |...|.||..||. |||:...
Mouse   279 YTVSVFTKAIISENPCI---------KHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGG 334

  Fly  1038 PVTVKSGAILRRPVCRER-------------WELSNDDVVLLERIGRGNFGDVYKAK-LKSTKLD 1088
            .||     .||.|||..|             |.:...::..::.||.|.||.|:... |...|
Mouse   335 LVT-----RLRYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDK-- 392

  Fly  1089 VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN 1153
            ||:||.:.....|:  .|::|..::.:..||.:|:|.|:|:::.||.:|.|.:..|.|..|||..
Mouse   393 VAIKTIQEGAMSEE--DFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQ 455

  Fly  1154 SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVS 1216
            .........:|||.|...||.|||....||||||||||||.....:|:|||||:|  .:::|..|
Mouse   456 RGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSS 520

  Fly  1217 DGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPT 1281
            .|.| .||||.:||..:|.:|:|..||||:|:||||:||:|..||...:||...|.|.||:|:..
Mouse   521 TGTK-FPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYK 584

  Fly  1282 PKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            |:.....:|::|..||....|.||.|.::
Mouse   585 PRLASCHVYQIMNHCWKEKPEDRPPFSQL 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/108 (25%)
		TyrKc	1063..1311	CDD:197581	101/251 (40%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/247 (41%)
Itk	NP_001268894.1	PH	5..117	CDD:278594	22/113 (19%)
		PH_Btk	7..154	CDD:269944	33/177 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..174		6/38 (16%)
		SH3_ITK	180..235	CDD:212841	8/54 (15%)
		SH2_Tec_Itk	238..345	CDD:198259	32/120 (27%)
		PTKc_Itk	363..618	CDD:133243	101/256 (39%)
		Pkinase_Tyr	368..617	CDD:285015	101/251 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910