DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Igf1r

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006540704.1	Gene:	Igf1r / 16001	MGIID:	96433	Length:	1401	Species:	Mus musculus

Alignment Length:	1441	Identity:	293/1441 - (20%)
Similarity:	497/1441 - (34%)	Gaps:	483/1441 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 DVRDKYQKACRKLHLTHNE---YVLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQ 232
            |:|:.||:..|..:.|..|   ::|.|::|    :|:|:...|.|     :|...::||:|  :.
Mouse    38 DIRNDYQQLKRLENCTVIEGFLHILLISKA----EDYRSYRFPKL-----TVITEYLLLFR--VA 91

  Fly   233 EAAQYGD----LTADKYKEIQKRIDTVIGSINPTEEYGEFTEKYKTSPTTPL--------LFQFD 285
            .....||    ||..:..::......||..:...::.|.:..:..|.....:        |...|
Mouse    92 GLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTID 156

  Fly   286 ETLIQD-------------------IPGKLQSSTLTVDNLTVD-------WLRNRLQELEGAV-- 322
            .:||.|                   .||.|:...: .:..|::       |..||.|::..:|
Mouse   157 WSLILDAVSNNYIVGNKPPKECGDLCPGTLEEKPM-CEKTTINNEYNYRCWTTNRCQKMCPSVCG 220

  Fly   323 -RDCQEKQMKMIEHVNGG--SPVANGSIIS---------------------NG---------SNT 354
             |.|.|..........|.  :|..|.:.::                     .|         :|.
Mouse   221 KRACTENNECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANI 285

  Fly   355 SNGIQSNKDSL------CRQ----------SKDLNALRCQ---------EKQKQKLVDMIKCALN 394
            .|...|:.|..      |.|          ::.:..:.|:         |::|.|.:|.:..|
Mouse   286 PNAESSDSDGFVIHDDECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSA-- 348

  Fly   395 EVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFK 459
                 ::..||   ..|:.|.:.|     .:|.|:       |.:||....|::.::.|   :.|
Mouse   349 -----QMLQGC---TILKGNLLIN-----IRRGNN-------IASELENFMGLIEVVTG---YVK 390

  Fly   460 -RKSTPQPATPMTRS---------RQGRFNKLQPRSQSLGSL-------SVIRDGN-----GPSP 502
             |.|....:....::         .:|.::.....:|:|..|       ..:|.|.     .|..
Mouse   391 IRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKL 455

  Fly   503 A-----RYEPITNHRLRQA---ASVHYLGEEIA--------TSST-------------NPPDLTR 538
            .     |.|.:|..:.||:   .:....||..:        ||:|             .|||...
Mouse   456 CVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRD 520

  Fly   539 L-------------------RRTQC-----SMLCLG-----EDEEPVVLASPAPLTQ----LTAA 570
            |                   .:..|     :|:.:.     |.|..::|....|.||    :.|.
Mouse   521 LISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAV 585

  Fly   571 VLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNR 635
            .||...|:||                  :|    .|.|.:.|..|.:.|...:|. |...:..::
Mouse   586 TLTMVENDHI------------------RG----AKSEILYIRTNASVPSIPLDV-LSASNSSSQ 627

  Fly   636 VLDDRLKRTL--------------QPSD------------DVNAIESAEENHIQTRKLAKDPDSQ 674
            ::......||              ||.|            |...|....:..|...::.::|  :
Mouse   628 LIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKADKIPIRKYADGTIDVEEVTENP--K 690

  Fly   675 TKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRT 739
            |:........|.:...|...|:...  .:.....:|.|...           |.|.....:.:|.
Mouse   691 TEVCGGDKGPCCACPKTEAEKQAEK--EEAEYRKVFENFLH-----------NSIFVPRPERRRR 742

  Fly   740 QPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKEN 804
            ...|         ..|::.||.:.|                        ||...|...|.|.:..
Mouse   743 DVMQ---------VANTTMSSRSRN------------------------TTVADTYNITDPEEFE 774

  Fly   805 SRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAG 869
            :...|...::..|.:    |..|.|..|.|.|..          ||        :...|.|:...
Mouse   775 TEYPFFESRVDNKER----TVISNLRPFTLYRID----------IH--------SCNHEAEKLGC 817

  Fly   870 SAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVL--- 931
            ||::..|....||           .|..|.|...:.....|||   |.....|.::.:..:|
Mouse   818 SASNFVFARTMPA-----------EGADDIPGPVTWEPRPENS---IFLKWPEPENPNGLILMYE 868

  Fly   932 -----SMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEES 991
                 .::|...||           :|..|.:  :.|.    ::.||  |.|::    |.|.:.:
Mouse   869 IKYGSQVEDQRECV-----------SRQEYRK--YGGA----KLNRL--NPGNY----TARIQAT 910

  Fly   992 QIVLSVCWNGHKHFIV--QTTGE-------------------------------GNFRF-EGPPF 1022
            .:..:..|.....|.|  :||.|                               .|.|. .|..:
Mouse   911 SLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGVLY 975

  Fly  1023 ASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKL 1087
            ||:..    :|.|...|.|.           :.||::.:.:.:...:|:|:||.||:...|....
Mouse   976 ASVNP----EYFSAADVYVP-----------DEWEVAREKITMNRELGQGSFGMVYEGVAKGVVK 1025

  Fly  1088 D-----VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLL 1147
            |     ||:||........::.:||.|..::|:::..::|:|:|:..|.||.:::|||:..|.|.
Mouse  1026 DEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLK 1090

  Fly  1148 TYLRK-----------NS-------------------------NGL-----TTRQQMGMCRDAAA 1171
            :|||.           ||                         |.|     :..:.:.|..:.|.
Mouse  1091 SYLRSLRPEVEPRLSWNSLRRPGWPRTLRDSLASVSQVLALKQNNLVLIPPSLSKMIQMAGEIAD 1155

  Fly  1172 GMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNF 1234
            ||.||.:...:|||||||||:|..:.:|||.||||:|:  |.:|....|...:||:|.:||:|..
Mouse  1156 GMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKD 1220

  Fly  1235 GKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAA 1299
            |.:|:..||||:|:::|||.:..:.||.|::|.:....:..|..:..|.:.|:.::.||..||..
Mouse  1221 GVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQY 1285

  Fly  1300 DAESRPHFDEI 1310
            :.:.||.|.||
Mouse  1286 NPKMRPSFLEI 1296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	22/78 (28%)
		SH2_Fps_family	953..1039	CDD:198224	22/119 (18%)
		TyrKc	1063..1311	CDD:197581	93/296 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	93/292 (32%)
Igf1r	XP_006540704.1	Recep_L_domain	51..159	CDD:366426	23/118 (19%)
		Furin-like	175..332	CDD:366287	23/157 (15%)
		Recep_L_domain	353..466	CDD:366426	24/130 (18%)
		FN3	494..607	CDD:238020	25/134 (19%)
		FN3	612..>656	CDD:238020	7/44 (16%)
		FN3	837..926	CDD:238020	21/114 (18%)
		PTKc_InsR_like	994..1302	CDD:173625	95/303 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910