DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and CSK

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001120662.1	Gene:	CSK / 1445	HGNCID:	2444	Length:	450	Species:	Homo sapiens

Alignment Length:	366	Identity:	129/366 - (35%)
Similarity:	185/366 - (50%)	Gaps:	32/366 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 WFHGVLPREEVVRLL--NNDGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRFEGPP 1021
            ||||.:.||:..|||  ...|.|||||: .|......|.|..:|. :|:.:..........|...
Human    82 WFHGKITREQAERLLYPPETGLFLVRES-TNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVY 145

  Fly  1022 FASIQELIMHQYHSEL---------PVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDV 1077
            |.::.:|:.| |.|:.         |..::.....:....|..|.|:..::.||:.||:|.||||
Human   146 FENLMQLVEH-YTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDV 209

  Fly  1078 YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICV-QKQPIMIVMELV 1141
            .....:..|  ||||..:   .|...:.||.|..::.|..|.|:|:|:|:.| :|..:.||.|.:
Human   210 MLGDYRGNK--VAVKCIK---NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYM 269

  Fly  1142 LGGSLLTYLRKNSNGLTTRQQMGMC-----RDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKI 1201
            ..|||:.|||.....:..    |.|     .|....|.|||..|.:||||||||.||..::..|:
Human   270 AKGSLVDYLRSRGRSVLG----GDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKV 330

  Fly  1202 SDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTN 1266
            ||||:::|...   :....::||||||||||...|:::..||||:|||:|||:|.|..||..:..
Human   331 SDFGLTKEASS---TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392

  Fly  1267 SRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            .....|::.||:|..|...|..:|.:|..||..||..||.|
Human   393 KDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSF 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	26/90 (29%)
		TyrKc	1063..1311	CDD:197581	99/251 (39%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/247 (39%)
CSK	NP_001120662.1	Interaction with PTPN22. /evidence=ECO:0000250\|UniProtKB:P41241	9..70
		SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190	27/94 (29%)
		PTKc_Csk	188..443	CDD:133213	101/258 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910