DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and CSF1R

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001275634.1	Gene:	CSF1R / 1436	HGNCID:	2433	Length:	972	Species:	Homo sapiens

Alignment Length:	383	Identity:	111/383 - (28%)
Similarity:	166/383 - (43%)	Gaps:	101/383 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1015 FRFEGPPFASIQELIMHQYH---------SELPVTVKSGAILRRPVCRERWELSNDDVVLLERIG 1070
            ::::..|...::..|:..|.         ::||.             .|:||...:::...:.:|
Human   538 YKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPY-------------NEKWEFPRNNLQFGKTLG 589

  Fly  1071 RGNFGDVYKAKL-----KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQY-DHPNIVKLIGICV 1129
            .|.||.|.:|..     :...|.||||..:.|...::|...:.|.:|:... .|.|||.|:|.|.
Human   590 AGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT 654

  Fly  1130 QKQPIMIVMELVLGGSLLTYLRK--------------------------------------NSNG 1156
            ...|::::.|....|.||.:||:                                      :|.|
Human   655 HGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQG 719

  Fly  1157 LTT------------------------------RQQMGMCRDAAAGMRYLESKNCIHRDLAARNC 1191
            :.|                              |..:......|.||.:|.||||||||:||||.
Human   720 VDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNV 784

  Fly  1192 LVDLEHSVKISDFGMSRE---EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEI 1253
            |:...|..||.|||::|:   :..|||. |..::||||.|||::....||...||||||||:|||
Human   785 LLTNGHVAKIGDFGLARDIMNDSNYIVK-GNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEI 848

  Fly  1254 FSKGDTPYSG-MTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            ||.|..||.| :.||:..:.:..||:|..|...|:.:|.:|..|||.:...||.|.:|
Human   849 FSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	4/32 (13%)
		TyrKc	1063..1311	CDD:197581	103/326 (32%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/322 (32%)
CSF1R	NP_001275634.1	IG_like	28..85	CDD:214653
		ig	207..293	CDD:365836
		Ig4_SCFR_like	299..400	CDD:319281
		Ig	416..495	CDD:319273
		Regulatory juxtamembrane domain	542..574		5/44 (11%)
		PTKc_CSF-1R	543..914	CDD:133237	111/378 (29%)
		Activation loop	796..818		8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910