DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Fnbp1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006497754.1	Gene:	Fnbp1 / 14269	MGIID:	109606	Length:	649	Species:	Mus musculus

Alignment Length:	724	Identity:	140/724 - (19%)
Similarity:	253/724 - (34%)	Gaps:	242/724 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LDHQAKQFKFNAEQLEV---VCDKLTHLSQDKRKARKAYQEEHAKIAA------RLNHLTD---- 131
            :|...|..||..|:.|:   ...:|.:||:..:..:.:.:||..|..|      .||.:.|
Mouse    22 IDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTACKAFLSTLNEMNDYAGQ 86

  Fly   132 -EVVRKKSEYQKHLEGYKALRTRFEENYIKAPSRSGRK-----------LDDVRDKYQKACRKLH 184
             ||:.:....|..::..:.::...:|.  |:....|||           |:..:.::::.|::..
Mouse    87 HEVISENMTSQITVDLMRYVQELKQER--KSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEAD 149

  Fly   185 LTHNEYV-----LSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADK 244
            .....:.     :::|:| :|||           ..||:          .|.|:.|:  |..||
Mouse   150 RAQQYFEKMDADINVTKA-DVEK-----------ARQQA----------QIRQQMAE--DSKAD- 189

  Fly   245 YKEIQKRIDTVIGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVD 309
            |..|.:|.:         :|..|:   |.|.  .|.:||           |:|           :
Mouse   190 YSLILQRFN---------QEQWEY---YHTH--IPNIFQ-----------KIQ-----------E 218

  Fly   310 WLRNRLQELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNA 374
            ....|:..:..:::...|...::|       |:....:               |.:.:.::.::
Mouse   219 MEERRIVRIGESMKTYAEVDRQVI-------PIIGKCL---------------DGIVKAAESID- 260

  Fly   375 LRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRS---NSTSSPGLG 436
               |:...|.:|:..|......|          |:..|.      |....:|:   ||.||...|
Mouse   261 ---QKNDSQLVVEAYKSGFEPPG----------DIEFED------YTQPMKRTVSDNSLSSSKEG 306

  Fly   437 IMNELMRRGGVLTLLRGRGRHF----KRK------STPQPATPMTRSRQGRFNKLQPRSQSLGSL 491
              ...:|.||     :.||:.:    |.|      |..||..|            .|.|.|..::
Mouse   307 --KPELRFGG-----KSRGKLWPFIKKNKLMSLLTSPHQPPPP------------PPASASPSAV 352

  Fly   492 SVIRDGNGP-SPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRR-TQCSMLCLGEDEE 554
            .     ||| ||.:.:...:||.          .|..||.........|:| ||  .||..::..
Mouse   353 P-----NGPQSPKQPKEPLSHRF----------NEFMTSKPKIHCFRSLKRGTQ--SLCYHKELM 400

  Fly   555 PVVLASPAPLTQLTAAVLTNTNNNHIYADLELDKKKDTSPS------PECKGEQIQPKKEQIRIE 613
            ...|..|....:.              .|..|..|...:|.      ||.:.:::|.|.:.:..|
Mouse   401 KRTLGKPTHALEA--------------RDYVLSLKLGVTPEDFSNFPPEQRRKKLQQKVDDLNRE 451

  Fly   614 INQTAPQNSIDAHLDRIDELNRV------------LDDRLKRTLQPSDDVNAIESAE-------- 658
            |.:...|.      |.|.::..|            ||.:|....|..:.:. :|:.:
Mouse   452 IQKETDQR------DAITKMKDVYLKNPQMGDPASLDQKLTEVTQNIEKLR-LEAQKFEAWLAEV 509

  Fly   659 ENHI-----QTRKLAKDPDSQTKRSSSSSSECR-SSKDTSHSKKRSLSFSQKSISNIFSNLKEF- 716
            |..:     |.|:.:...|.||.::.::.::.| ||.|.|:::::|.....|.::..|.:  ||
Mouse   510 EGRLPARSEQARRQSGLYDGQTHQTVTNCAQDRESSPDGSYTEEQSQESEHKVLAPDFDD--EFD 572

  Fly   717 SKSPLVRMG 725
            .:.||..:|
Mouse   573 DEEPLPAIG 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	37/192 (19%)
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
Fnbp1	XP_006497754.1	F-BAR_FBP17	5..257	CDD:153360	56/319 (18%)
		HR1	434..510	CDD:381797	15/82 (18%)
		SH3_FBP17	581..637	CDD:213004	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910