DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Fgfr4

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006517162.3	Gene:	Fgfr4 / 14186	MGIID:	95525	Length:	829	Species:	Mus musculus

Alignment Length:	486	Identity:	135/486 - (27%)
Similarity:	211/486 - (43%)	Gaps:	115/486 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   915 DIDNDEEE---------EDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEV 970
            ||::.|.|         ||:.....|:           ..||.||     |:..|. .|||.|::
Mouse   336 DINSSEVEVLYLRNVSAEDAGEYTCLA-----------GNSIGLS-----YQSAWL-TVLPEEDL 383

  Fly   971 VRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHS 1035
            .         ....|.....:.|:|.|  :|....:|.....|.:..:          ::..::|
Mouse   384 T---------WTTATPEARYTDIILYV--SGSLVLLVLLLLAGVYHRQ----------VIRGHYS 427

  Fly  1036 ELPVTVKSGAILRRPVCRE-----------------------------------------RWELS 1059
            ..|||::.  :.|.|:.|:                                         .||..
Mouse   428 RQPVTIQK--LSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVNLDLPLDPLWEFP 490

  Fly  1060 NDDVVLLERIGRGNFGDVYKAK---LKSTKLD----VAVKTCRMTLPDEQKRKFLQEGRILKQYD 1117
            .|.:||.:.:|.|.||.|.:|:   :..::.|    ||||..:....|:.....:.|..::|...
Mouse   491 RDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIG 555

  Fly  1118 -HPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR--------------KNSNGLTTRQQMGMCR 1167
             |.||:.|:|:|.|:.|:.:::|....|:|..:||              ::|.|..:...:..|.
Mouse   556 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCA 620

  Fly  1168 -DAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAP 1229
             ..|.||:||||:.||||||||||.||..:..:||:|||::|  ...:|.......::||||.||
Mouse   621 YQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAP 685

  Fly  1230 EALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLML 1294
            |||....||...||||:|||:||||:.|.:||.|:........:..|:||..|.:.|.|:|.||.
Mouse   686 EALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMR 750

  Fly  1295 QCWAADAESRPHFDEIYNVVDALILRLDNSH 1325
            :||.|....||.|.::...:|.::|.:...:
Mouse   751 ECWHAAPSQRPTFKQLVEALDKVLLAVSEEY 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	14/85 (16%)
		TyrKc	1063..1311	CDD:197581	99/272 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/272 (36%)
Fgfr4	XP_006517162.3	IGc2	77..134	CDD:197706
		Ig	184..268	CDD:386229
		Ig3_FGFR-2	291..378	CDD:143266	13/58 (22%)
		PTKc_FGFR4	481..794	CDD:133230	104/301 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810