DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Fgfr3

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001156689.1	Gene:	Fgfr3 / 14184	MGIID:	95524	Length:	802	Species:	Mus musculus

Alignment Length:	333	Identity:	112/333 - (33%)
Similarity:	164/333 - (49%)	Gaps:	59/333 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1018 EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKA-- 1080
            |||..|::.||       |||...|             ||||...:.|.:.:|.|.||.|..|
Mouse   443 EGPVLANVSEL-------ELPADPK-------------WELSRTRLTLGKPLGEGCFGQVVMAEA 487

  Fly  1081 ----KLKSTK-LDVAVKTCRMTLPDEQKRKFLQEGRILKQY-DHPNIVKLIGICVQKQPIMIVME 1139
                |.::.| :.||||..:....|:.....:.|..::|.. .|.||:.|:|.|.|..|:.:::|
Mouse   488 IGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVE 552

  Fly  1140 LVLGGSLLTYLRKNSNGLTTRQQMGM---------------CRD-------AAAGMRYLESKNCI 1182
            ....|:|..:||       .|:..||               |:|       .|.||.||.|:.||
Mouse   553 YAAKGNLREFLR-------ARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCI 610

  Fly  1183 HRDLAARNCLVDLEHSVKISDFGMSREEE--EYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWS 1245
            ||||||||.||..::.:||:|||::|:..  :|.......::||||.|||||....||...||||
Mouse   611 HRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 675

  Fly  1246 YGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            :|:|:||||:.|.:||.|:......:.:..|:||..|.|...::|.:|.:||.|....||.|.::
Mouse   676 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQL 740

  Fly  1311 YNVVDALI 1318
            ...:|.::
Mouse   741 VEDLDRIL 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	8/20 (40%)
		TyrKc	1063..1311	CDD:197581	97/279 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	96/279 (34%)
Fgfr3	NP_001156689.1	IGc2	51..110	CDD:197706
		IG	52..108	CDD:214652
		Ig2_FGFR	155..239	CDD:143265
		IG_like	254..349	CDD:214653
		Ig3_FGFR	262..350	CDD:143175
		PTKc_FGFR3	455..788	CDD:173652	105/314 (33%)
		Pkinase_Tyr	468..744	CDD:285015	97/282 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900