DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Fgfr2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_034337.2	Gene:	Fgfr2 / 14183	MGIID:	95523	Length:	840	Species:	Mus musculus

Alignment Length:	437	Identity:	125/437 - (28%)
Similarity:	191/437 - (43%)	Gaps:	70/437 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   921 EEEDSASDDVLSMKDHCYCVPSLAASI--------SLSTNRPLYEEE-WFHGVLPREEVVRLLNN 976
            |:|.:||.|.|.:..:|..|..:|..:        ..:|.:|.:..: ..|.:..|..:.|
Mouse   385 EKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRR---- 445

  Fly   977 DGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTV 1041
                  :.|:..|.|..:.|      ...:|:.|...:...:.|..|.:.|.       |||...
Mouse   446 ------QVTVSAESSSSMNS------NTPLVRITTRLSSTADTPMLAGVSEY-------ELPEDP 491

  Fly  1042 KSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-------VAVKTCRMTLP 1099
            |             ||...|.:.|.:.:|.|.||.|..|:......|       ||||..:....
Mouse   492 K-------------WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDAT 543

  Fly  1100 DEQKRKFLQEGRILKQY-DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN---------- 1153
            ::.....:.|..::|.. .|.||:.|:|.|.|..|:.:::|....|:|..|||..
Mouse   544 EKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYD 608

  Fly  1154 -----SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EE 1211
                 ...:|.:..:......|.||.||.|:.||||||||||.||...:.:||:|||::|:  ..
Mouse   609 INRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 673

  Fly  1212 EYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTG 1276
            :|.......::||||.|||||....||...||||:|:||||||:.|.:||.|:......:.:..|
Mouse   674 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 738

  Fly  1277 YRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            :||..|.:...|:|.:|..||.|....||.|.::...:|.::....|
Mouse   739 HRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/86 (17%)
		TyrKc	1063..1311	CDD:197581	93/272 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	92/272 (34%)
Fgfr2	NP_034337.2	Ig	66..143	CDD:325142
		Ig2_FGFR	183..267	CDD:143265
		Ig3_FGFR-2	290..379	CDD:143266
		PTKc_FGFR2	475..787	CDD:270679	105/331 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810