Protein Alignment FER and Fgfr2

DIOPT Version :10

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_034337.2
• Gene: Fgfr2 / 14183
• MGIID: 95523
• Length: 840
• Species: Mus musculus
• Alignment Length: 437
• Identity: 125/437 - (28%)
• Similarity: 191/437 - (43%)
• Gaps: 70/437 - (16%)

  Fly   921 EEEDSASDDVLSMKDHCYCVPSLAASI--------SLSTNRPLYEEE-WFHGVLPREEVVRLLNN 976
            |:|.:||.|.|.:..:|..|..:|..:        ..:|.:|.:..: ..|.:..|..:.|
Mouse   385 EKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRR---- 445

  Fly   977 DGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTV 1041
                  :.|:..|.|..:.|      ...:|:.|...:...:.|..|.:.|.       |||...
Mouse   446 ------QVTVSAESSSSMNS------NTPLVRITTRLSSTADTPMLAGVSEY-------ELPEDP 491

  Fly  1042 KSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-------VAVKTCRMTLP 1099
            |             ||...|.:.|.:.:|.|.||.|..|:......|       ||||..:....
Mouse   492 K-------------WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDAT 543

  Fly  1100 DEQKRKFLQEGRILKQY-DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN---------- 1153
            ::.....:.|..::|.. .|.||:.|:|.|.|..|:.:::|....|:|..|||..
Mouse   544 EKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYD 608

  Fly  1154 -----SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EE 1211
                 ...:|.:..:......|.||.||.|:.||||||||||.||...:.:||:|||::|:  ..
Mouse   609 INRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 673

  Fly  1212 EYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTG 1276
            :|.......::||||.|||||....||...||||:|:||||||:.|.:||.|:......:.:..|
Mouse   674 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 738

  Fly  1277 YRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            :||..|.:...|:|.:|..||.|....||.|.::...:|.::....|
Mouse   739 HRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/86 (17%)
		PTKc_Fes_like	1067..1315	CDD:270637	92/272 (34%)
Fgfr2	NP_034337.2	Ig	50..143	CDD:472250
		Ig strand B	77..81	CDD:409353
		Ig strand C	88..92	CDD:409353
		Ig strand E	109..113	CDD:409353
		Ig strand F	123..128	CDD:409353
		Ig strand G	136..139	CDD:409353
		IgI_2_FGFR	173..267	CDD:409443
		Ig strand A	173..176	CDD:409443
		Ig strand A'	184..189	CDD:409443
		Ig strand B	193..201	CDD:409443
		Ig strand C	207..212	CDD:409443
		Ig strand C'	215..217	CDD:409443
		Ig strand D	226..229	CDD:409443
		Ig strand E	233..238	CDD:409443
		Ig strand F	247..254	CDD:409443
		Ig strand G	257..267	CDD:409443
		IgI_3_FGFR2	275..379	CDD:409444
		Ig strand A	275..278	CDD:409444
		Ig strand A'	282..286	CDD:409444
		Ig strand B	294..301	CDD:409444
		Ig strand C	305..312	CDD:409444
		Ig strand D	327..332	CDD:409444
		Ig strand E	344..349	CDD:409444
		Ig strand F	357..365	CDD:409444
		Ig strand G	368..376	CDD:409444
		PTKc_FGFR2	475..787	CDD:270679	105/331 (32%)