DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Fer

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001033086.2	Gene:	Fer / 14158	MGIID:	105917	Length:	823	Species:	Mus musculus

Alignment Length:	1319	Identity:	342/1319 - (25%)
Similarity:	522/1319 - (39%)	Gaps:	515/1319 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGFSSALQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYAISLTAVAQQGLKIDRADEMQ 65
            |||.|.|::  :.||::..||.||||:||:|:.:.::.|.|||||.:|..:..|   :|:...:|
Mouse     1 MGFGSDLKN--SQEAVLKLQDWELRLLETVKKFMALRIKSDKEYAYTLQNLCNQ---VDKESTVQ 60

  Fly    66 ---GSLISKSWRSYMDELDHQAKQFKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEHAKIAARL 126
               .|.:||||...:.:.:..::..|.:||.|.. ...:||.:.:||::.:|:|...|.:|.|.:
Mouse    61 VNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYVGIHQQIEAEM 125

  Fly   127 NHLT-DEVVRKKSEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQKACRKLHLTHNEY 190
            ..:| .|:.:.||.|::.::...:.:.:::|...|     |::.:..:::|.||..|||:.||:|
Mouse   126 IKVTKTELEKLKSSYRQLIKEMNSAKEKYKEALAK-----GKETEKAKERYDKATMKLHMLHNQY 185

  Fly   191 VLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRIDTV 255
            ||::..|...:..:.:..||.||:..|.:||..|...:.|..:.:|...|..::...:.|.|...
Mouse   186 VLALKGAQLHQSQYYDTTLPLLLDSVQKMQEEMIKALKGIFDDYSQITSLVTEEIVNVHKEIQMS 250

  Fly   256 IGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRLQELEG 320
            :..|:|:.||..|.:.::|:.......:||.:|::: ...||::.:..:|||.|.|:..|:.|..
Mouse   251 VEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEE-NENLQANEIMWNNLTADSLQVMLKTLAE 314

  Fly   321 AVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQEKQKQKL 385
            .:...|:    |:.|       ...:::..........::     |.:..|:..|.   .|||.|
Mouse   315 ELTQTQQ----MLLH-------KEAAVLELEKRIEESFET-----CEKKSDIVLLL---GQKQAL 360

  Fly   386 VDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTL 450
             :.:|.::.::.|.|........| |||...||
Mouse   361 -EELKQSVQQLRCTEAKCAAQKAL-LEQKVQEN-------------------------------- 391

  Fly   451 LRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQ 515
                                                         ||..|.|.
Mouse   392 ---------------------------------------------DGKEPPPV------------ 399

  Fly   516 AASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHI 580
               |:|  ||.|.|.|:
Mouse   400 ---VNY--EEDARSVTS------------------------------------------------ 411

  Fly   581 YADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTL 645
                 :::|:..|            |.|.||
Mouse   412 -----MERKERLS------------KFESIR---------------------------------- 425

  Fly   646 QPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIF 710
                                                                      .||:.|.
Mouse   426 ----------------------------------------------------------HSIAGII 432

  Fly   711 SNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSN 775
                   |||
Mouse   433 -------KSP------------------------------------------------------- 435

  Fly   776 HSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPC 840

Mouse   436 ----------------------------------------------------------------- 435

  Fly   841 KQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSS 905
                        |||.            ||:.  |.|
Mouse   436 ------------KSVL------------GSST--QVC---------------------------- 446

  Fly   906 GELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEV 970
                                   ||:|:.:                 |||.|.:|:||.:||.|.
Mouse   447 -----------------------DVISVGE-----------------RPLAEHDWYHGAIPRIEA 471

  Fly   971 VRLLNNDGDFLVRETIRNEESQIVLSVCWNG-HKHFIVQTTGEGNFRFEGPPFASIQELIMHQYH 1034
            ..||...|||||||: ..:..:.||||..:| .:|||:|.. :..:||||..|::|.:||.|.::
Mouse   472 QELLKQQGDFLVRES-HGKPGEYVLSVYSDGQRRHFIIQFV-DNLYRFEGTGFSNIPQLIDHHFN 534

  Fly  1035 SELPVTVKSGAILRRPVCRE-RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTL 1098
            ::..:|.|||.:|..|:.:: :|.|:::||.|.|.:|:||||:|||..||. |..||:|||:..|
Mouse   535 TKQVITKKSGVVLLNPIPKDKKWVLNHEDVSLGELLGKGNFGEVYKGTLKD-KTPVAIKTCKEDL 598

  Fly  1099 PDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQM 1163
            |.|.|.|||||.:|||||||||||||||:|.|:||:.|:||||.||..||:|||..:.|..:|.:
Mouse   599 PQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLTFLRKRKDELKLKQLV 663

  Fly  1164 GMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIV-SDGMKQIPVKWT 1227
            ....|.||||.|||||||||||||||||||...:::|||||||||:|:..:. |.|:||||:|||
Mouse   664 RFSLDVAAGMLYLESKNCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWT 728

  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRL 1292
            ||||||:|:|:|..||||:|||:||.||.|..||.||||.:|||:::.||||..|::.|||::.:
Mouse   729 APEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEVFTI 793

  Fly  1293 MLQCWAADAESRPHFDEIY 1311
            |::||....|:||.|::::
Mouse   794 MMKCWDYKPENRPKFNDLH 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	71/240 (30%)
		SH2_Fps_family	953..1039	CDD:198224	37/86 (43%)
		TyrKc	1063..1311	CDD:197581	149/248 (60%)
		PTKc_Fes_like	1067..1315	CDD:270637	147/246 (60%)
Fer	NP_001033086.2	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300		88/309 (28%)
		F-BAR_Fer	5..238	CDD:153370	72/242 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..408		11/112 (10%)
		SH2_Fps_family	454..539	CDD:198224	37/86 (43%)
		PKc_like	567..817	CDD:419665	147/247 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	312	1.000	Domainoid score	I1309
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74300
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1145
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm44118
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3894
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860