DRSC/TRiP Functional Genomics Resources

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Protein Alignment FER and Ephb4

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_001153043.1 Gene:Ephb4 / 13846 MGIID:104757 Length:996 Species:Mus musculus


Alignment Length:688 Identity:181/688 - (26%)
Similarity:278/688 - (40%) Gaps:209/688 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   752 CPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENS--RLKFKVPKI 814
            ||.||.|    ||..:........:..::|...:|..||..:...:.......|  ||::..|  
Mouse   288 CPANSHS----NNIGSPVCLCRIGYYRARSDPRSSPCTTPPSAPRSVVHHLNGSTLRLEWSAP-- 346

  Fly   815 QKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNC 879
                  :.:..|.. |.:.::    |::|                      :|.||        |
Mouse   347 ------LESGGRED-LTYAVR----CREC----------------------RPGGS--------C 370

  Fly   880 PPAG---------QKPVKPSVQISGHKDH---------------------PFESSSGELDENSDR 914
            .|.|         :..|:|.|.|.|.:..                     |||    .::..:||
Mouse   371 LPCGGDMTFDPGPRDLVEPWVAIRGLRPDVTYTFEVAALNGVSTLATGPPPFE----PVNVTTDR 431

  Fly   915 D-------------IDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHG--- 963
            :             :.:......|.|..:||     :.:|. |.|.::......|.|:...|   
Mouse   432 EGRIGFLSPAVPPAVSDIRVTRSSPSSLILS-----WAIPR-APSGAVLDYEVKYHEKGAEGPSS 490

  Fly   964 --VLPREE---VVRLLNNDGDFLVRETIRNE------------ESQIVLSVCW------------ 999
              .|...|   .:|.|.....:||:...|:|            ::|:..|..|            
Mouse   491 VRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLALIAGTAV 555

  Fly  1000 ---------------------NG--------HKHFIVQTTGEGN------FRFEGPPFASIQELI 1029
                                 ||        |..:::   |.|.      |.:|.|..|      
Mouse   556 VGVVLVLVVVIIAVLCLRKQSNGREVEYSDKHGQYLI---GHGTKVYIDPFTYEDPNEA------ 611

  Fly  1030 MHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKS---TKLDVAV 1091
            :.::..|:.|:.                     |.:.|.||.|.||:|.:.:||:   .:..||:
Mouse   612 VREFAKEIDVSY---------------------VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAI 655

  Fly  1092 KTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG 1156
            ||.:....:.|:|:||.|..|:.|::||||::|.|:.....|:||:.|.:..|:|.::||.|...
Mouse   656 KTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQ 720

  Fly  1157 LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE------YIV 1215
            .|..|.:||.|..|:|||||...:.:||||||||.||:.....|:||||:||..||      |..
Mouse   721 FTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTS 785

  Fly  1216 SDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMP 1280
            |.|.| ||::||||||:.|.|:||..|.|||||:|||:.|.|:.||..|:|......|:..||:|
Mouse   786 SLGGK-IPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLP 849

  Fly  1281 TPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            .|...|..:::|||.||..|..:||.|.::.:.:|.:|
Mouse   850 PPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMI 887

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 24/152 (16%)
TyrKc 1063..1311 CDD:197581 112/256 (44%)
PTKc_Fes_like 1067..1315 CDD:270637 111/256 (43%)
Ephb4NP_001153043.1 EphR_LBD_B4 17..196 CDD:198442
FN3 324..429 CDD:238020 22/151 (15%)
FN3 443..535 CDD:238020 18/97 (19%)
EphA2_TM <571..619 CDD:291255 9/56 (16%)
PTKc_EphR_B 619..887 CDD:173638 114/289 (39%)
Pkinase_Tyr 624..883 CDD:285015 112/259 (43%)
SAM 913..980 CDD:197735
SAM_EPH-B4 916..982 CDD:188953
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 974..996
PDZ-binding. /evidence=ECO:0000255 994..996
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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