DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Ephb3

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006521851.1	Gene:	Ephb3 / 13845	MGIID:	104770	Length:	1048	Species:	Mus musculus

Alignment Length:	821	Identity:	212/821 - (25%)
Similarity:	317/821 - (38%)	Gaps:	243/821 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   540 RRTQCSMLCLG-----EDEEPVVLASPAPLTQLTAAVLTNTNNNHIYADLE-LDKKKDTSPSPEC 598
            :.:||.....|     :.|.|.:...|...|...||.:...:||...||.: .|....|.|||
Mouse   272 KESQCRACPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSP-- 334

  Fly   599 KGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDV--NAIESAEENH 661
                                |:..|    ..::|.:.:|:....|.|...||:  |.|
Mouse   335 --------------------PRGVI----SNVNETSLILEWSEPRDLGGRDDLLYNVI------- 368

  Fly   662 IQTRKLAKDPDSQTKRSSSSS---SECRSSKDTSHSKKRSLSFSQK--SISNIFSNLK------- 714
                       .:..|.||.:   :.|....|......|.|..:::  .||::.::.:
Mouse   369 -----------CKKCRGSSGAGGPATCSRCDDNVEFVPRQLGLTERRVHISHLLAHTRYTFEVQA 422

  Fly   715 ---EFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNH 776
               ...||||........:...|.|....|:.|.|         |||.||
Mouse   423 VNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLHLH---------SSSGSS--------------- 463

  Fly   777 SASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCK 841
                            .|.:...|.:.|..:.....|..:|||.|.:|..|:..:.||...:|..
Mouse   464 ----------------LTLSWAPPERPNGVILDYEMKYFEKSKGIASTVTSQKNSVQLDGLQPDA 512

  Fly   842 QCTKRRRI----------HPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGH 896
            :...:.|.          ||:        |||.....||.|.:.      ..|.|:.....::|.
Mouse   513 RYVVQVRARTVAGYGQYSHPA--------EFETTSERGSGAQQL------QEQLPLIVGSTVAGF 563

  Fly   897 KDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWF 961
                                             |..:      |..:.|.:.|...|
Mouse   564 ---------------------------------VFMV------VVVVIALVCLRKQR-------- 581

  Fly   962 HGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQ 1026
            ||            .|.::       .|:.|..::   .|.|.:|      ..|.:|.|..|
Mouse   582 HG------------PDAEY-------TEKLQQYIA---PGMKVYI------DPFTYEDPNEA--- 615

  Fly  1027 ELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLK---STKLD 1088
               :.::..|:.|:           |          |.:.|.||.|.||:|.:.:||   ..::.
Mouse   616 ---VREFAKEIDVS-----------C----------VKIEEVIGAGEFGEVCRGRLKLPGRREVF 656

  Fly  1089 VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN 1153
            ||:||.::...:.|:|.||.|..|:.|:|||||::|.|:..:.:|:||:.|.:...:|.::||.|
Mouse   657 VAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLN 721

  Fly  1154 SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE------ 1212
            ....|..|.:||.|..||||:||...|.:||||||||.||:.....|:||||:||..|:
Mouse   722 DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPT 786

  Fly  1213 YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY 1277
            |..|.|.| ||::||||||:.:.|:||..|||||||:|||:.|.|:.||..|:|......::..|
Mouse   787 YTSSLGGK-IPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDY 850

  Fly  1278 RMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            |:|.|...|..:::|||.||..|...||.|.:|.|.:|.||
Mouse   851 RLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLI 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	14/85 (16%)
		TyrKc	1063..1311	CDD:197581	111/256 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	112/256 (44%)
Ephb3	XP_006521851.1	EphR_LBD_B3	31..203	CDD:198446
		fn3	333..431	CDD:365830	22/141 (16%)
		FN3	<468..537	CDD:238020	17/76 (22%)
		EphA2_TM	572..623	CDD:373140	15/92 (16%)
		PTKc_EphR_B	623..891	CDD:173638	116/289 (40%)
		SAM_superfamily	917..985	CDD:387673
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910