DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Epha5

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006534832.1	Gene:	Epha5 / 13839	MGIID:	99654	Length:	1040	Species:	Mus musculus

Alignment Length:	1202	Identity:	270/1202 - (22%)
Similarity:	421/1202 - (35%)	Gaps:	413/1202 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 LWRNILQEAAQYGDLTADKYKEIQKRID--TVIGSI-------NPTEEYGEFTEKYKTSPTTPLL 281
            ||..:|..|| ...|.|....|: ..:|  ||:|.:       |..||.||..|.|....|
Mouse    42 LWTCLLLCAA-LRTLLASPSNEV-NLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHT---- 100

  Fly   282 FQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNR-----LQELEGAVRDCQEKQMKMIEHVNGGSP 341
            :|..:.:.|:     |::.|    || .|:.|.     ..||:..:|||
Mouse   101 YQVCKVMEQN-----QNNWL----LT-SWISNEGASRIFIELKFTLRDC---------------- 139

  Fly   342 VANGSIISNGSNTSNGIQSNKDSLCR---QSKDLNALRCQEKQKQKLVDMIKCALNEVGCEELPS 403
                      ::...|:.:.|::...   :|.|.|....:|.|..|:
Mouse   140 ----------NSLPGGLGTCKETFNMYYFESDDENGRSIKENQYIKI------------------ 176

  Fly   404 GCDDDLTLEQNFIENGYNNEQQRSNS-------TSSPG--------------------------- 434
               |.:..:::|.|....:...:.|:       .|..|
Mouse   177 ---DTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSV 238

  Fly   435 ---LGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSL-------- 488
               |.|..:.:.......||...|.......|..| ..|..|.:|.:  |.|..:.:
Mouse   239 VRHLAIFPDTITGADSSQLLEVSGSCVNHSVTDDP-PKMHCSAEGEW--LVPIGKCMCKAGYEEK 300

  Fly   489 -GSLSVIRDGNGPSPARYEPITNHRLRQAASVH-YLGEEIATSSTNPPDLTRLRRTQCSMLCLGE 551
             |:..|.|      |..::...:.:.......| |..||.:||.....|..|            :
Mouse   301 NGTCQVCR------PGFFKASPHSQTCSKCPPHSYTHEEASTSCVCEKDYFR------------K 347

  Fly   552 DEEPVVLASPAPLTQLTAAVLTNTNNNHIYAD----LELDKKKDTSPSPECK------------G 600
            |.:|..:|...|.:....|: :|.|...::.:    .:...:||.|....||            |
Mouse   348 DSDPPTMACTRPPSAPRNAI-SNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECG 411

  Fly   601 EQIQPKKEQIRIEINQTAPQNSIDAHLD---RIDELNRVLDDRLKRTLQPSD----DVNAIESAE 658
            ..::...:||.:: |.:.....:.||.:   .|:.:|.|.|      |.|..    .||
Mouse   412 GHVRYLPQQIGLK-NTSVMMVDLLAHTNYTFEIEAVNGVSD------LSPGTRQYVSVN------ 463

  Fly   659 ENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVR 723
               :.|.:.|..|.:..|:...:              |.|:|.|.:.
Mouse   464 ---VTTNQAAPSPVTNVKKGKIA--------------KNSISLSWQE------------------ 493

  Fly   724 MGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTI 788

Mouse   494 ----------------------------------------------------------------- 493

  Fly   789 TTTITTTTTTTPSKENS-RLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPS 852
                       |.:.|. .|::::...:|..:......:||..:...:..||......:.|...:
Mouse   494 -----------PDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPASVYVFQIRARTA 547

  Fly   853 KSVFDFAKEFEVE-QPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDI 916
            .....|::.||.| .|...||
Mouse   548 AGYGVFSRRFEFETTPVSVAA-------------------------------------------- 568

  Fly   917 DNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFL 981
            .||:.:                 :|.:|.|:::             ||:       ||.....||
Mouse   569 SNDQSQ-----------------IPIIAVSVTV-------------GVI-------LLAVMIGFL 596

  Fly   982 VRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAI 1046
            :..:..:.......|:|...|...|.:.   |..:.:..|  ..:::..|..|.:||.
Mouse   597 LSGSCCDCGCGRASSLCAVAHPSLIWRC---GYSKAKQDP--EEEKMHFHNGHIKLPG------- 649

  Fly  1047 LRRPVCRERWELSNDDV-----------VLLER-IGRGNFGDVYKAKLK---STKLDVAVKTCRM 1096
            :|..:....:|..|..|           :.:|| ||.|.||:|...:||   ..:|.||:||.::
Mouse   650 VRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKV 714

  Fly  1097 TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQ 1161
            ...::|:|.||.|..|:.|:|||||:.|.|:..:.:|:|||.|.:..|||.|:|:||....|..|
Mouse   715 GYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQ 779

  Fly  1162 QMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-----EEEEYIVSDGMKQ 1221
            .:||.|..||||:||.....:||||||||.|::.....|:||||:||     .|..|....|  :
Mouse   780 LVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG--K 842

  Fly  1222 IPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTP 1286
            ||::||||||:.|.|:||..|||||||:|||:.|.|:.||..|||....:.::.|||:|:|...|
Mouse   843 IPIRWTAPEAIAFRKFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCP 907

  Fly  1287 EEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            ..:|:|||.||..|..|||.||||.|::|.||
Mouse   908 AALYQLMLDCWQKDRNSRPKFDEIVNMLDKLI 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	6/16 (38%)
		SH2_Fps_family	953..1039	CDD:198224	15/85 (18%)
		TyrKc	1063..1311	CDD:197581	120/267 (45%)
		PTKc_Fes_like	1067..1315	CDD:270637	121/256 (47%)
Epha5	XP_006534832.1	EphR_LBD	62..234	CDD:383093	40/233 (17%)
		FN3	360..466	CDD:238020	22/122 (18%)
		FN3	471..561	CDD:238020	18/197 (9%)
		EphA2_TM	581..673	CDD:373140	21/123 (17%)
		PTKc_EphR_A	673..939	CDD:270651	122/267 (46%)
		SAM_EPH-A5	968..1033	CDD:188945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910