DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Epha4

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_031962.2	Gene:	Epha4 / 13838	MGIID:	98277	Length:	986	Species:	Mus musculus

Alignment Length:	1010	Identity:	238/1010 - (23%)
Similarity:	372/1010 - (36%)	Gaps:	300/1010 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   466 PATPMT----RSRQGRFNKL-QPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYLGEE 525
            ||..:|    ||.||....: .|.......:|::.:.|  :|.|...:.|  :.:|:..::|..:
Mouse    27 PANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKN--TPIRTYQVCN--VMEASQNNWLRTD 87

  Fly   526 IATSSTNPPDLTRLRRT--QCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHIYADLELDK 588
            ..|..........::.|  .|:.|       |.|:.:            .....|..|.:.:.||
Mouse    88 WITREGAQRVYIEIKFTLRDCNSL-------PGVMGT------------CKETFNLYYYESDNDK 133

  Fly   589 KKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDD----RLKRTLQPSD 649
            ::....|...|.:.|...:...:::|.            |||.:||..:.|    ..|.......
Mouse   134 ERFIRESQFGKIDTIAADESFTQVDIG------------DRIMKLNTEIRDVGPLSKKGFYLAFQ 186

  Fly   650 DVNAIESA-------EENHIQTRKLAKDPDSQTKRSSSS-------------------------- 681
            ||.|..:.       ::..:..|.||:.||:.|...:||
Mouse   187 DVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADG 251

  Fly   682 ------------------SSECRSSK---------DTSHSKKRSLSFS----------------- 702
                              :.||::.|         |.|.:|....|:|
Mouse   252 EWLVPIGNCLCNAGHEEQNGECQACKIGYYKALSTDASCAKCPPHSYSVWEGATSCTCDRGFFRA 316

  Fly   703 ------------QKSISNIFSNLKEFS-----KSPLVRMGKNHILNE-------EQDAKRTQP-- 741
                        ..:..|:.||:.|.|     .||....|:..|...       ..|..:.:|
Mouse   317 DNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCG 381

  Fly   742 -SQHHHSSGSDCPTNSSSSSSNNNNNN-------KNTSSNSNHSASQSTIITSTITTTITTTTTT 798
             ..|:....:...|...|.:....:.|       .|..|..|.|..||..:|.|......::...
Mouse   382 SGVHYTPQQNGLKTTRVSITDLLAHTNYTFEIWAVNGVSKYNPSPDQSVSVTVTTNQAAPSSIAL 446

  Fly   799 TPSKENSR-----------------LKFKVPKIQK-KSKAIRNTFRSKLLNFQLKRSKPCKQCTK 845
            ..:||.:|                 |:::|...:| :::......|:...|..:|...|......
Mouse   447 VQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVF 511

  Fly   846 RRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDE 910
            ..|...:....||::..||.           .|..|:         :|.|
Mouse   512 HVRARTAAGYGDFSEPLEVT-----------TNTVPS---------RIIG--------------- 541

  Fly   911 NSDRDIDNDEEEEDSASDDVL--SMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRL 973
                         |.|:..||  |:......|..|.|:..:|..|..|.:       .::|.
Mouse   542 -------------DGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSK-------AKQEA--- 583

  Fly   974 LNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELP 1038
                          :||..:...|           .|....|.:|.|..|      :.::..|:.
Mouse   584 --------------DEEKHLNQGV-----------RTYVDPFTYEDPNQA------VREFAKEID 617

  Fly  1039 VTVKSGAILRRPVCRERWELSNDDVVLLER-IGRGNFGDVYKAKLK---STKLDVAVKTCRMTLP 1099
            .:           |           :.:|: ||.|.||:|...:||   ..::.||:||.:....
Mouse   618 AS-----------C-----------IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYT 660

  Fly  1100 DEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMG 1164
            |:|:|.||.|..|:.|:|||||:.|.|:..:.:|:||:.|.:..|||..:||||....|..|.:|
Mouse   661 DKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVG 725

  Fly  1165 MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-----EEEEYIVSDGMKQIPV 1224
            |.|...:||:||...:.:||||||||.||:.....|:|||||||     .|..|....|  :||:
Mouse   726 MLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGG--KIPI 788

  Fly  1225 KWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEM 1289
            :||||||:.:.|:||..|||||||:|||:.|.|:.||..|:|....:.|:.|||:|.|...|..:
Mouse   789 RWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIAL 853

  Fly  1290 YRLMLQCWAADAESRPHFDEIYNVVDALILRLDNS 1324
            ::|||.||..:...||.|.:|.|::|.|| |..||
Mouse   854 HQLMLDCWQKERSDRPKFGQIVNMLDKLI-RNPNS 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	12/85 (14%)
		TyrKc	1063..1311	CDD:197581	111/256 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	113/256 (44%)
Epha4	NP_031962.2	EphR_LBD_A4	30..203	CDD:198450	37/207 (18%)
		FN3	329..436	CDD:238020	22/106 (21%)
		FN3	441..532	CDD:238020	15/101 (15%)
		EphA2_TM	562..616	CDD:291255	14/94 (15%)
		PTKc_EphR_A	616..882	CDD:270651	115/289 (40%)
		Pkinase_Tyr	621..878	CDD:285015	113/258 (44%)
		SAM_EPH-A4	911..981	CDD:188944
		SAM	915..975	CDD:197735
		PDZ-binding. /evidence=ECO:0000255	984..986
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910