DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Epha2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_034269.2	Gene:	Epha2 / 13836	MGIID:	95278	Length:	977	Species:	Mus musculus

Alignment Length:	293	Identity:	115/293 - (39%)
Similarity:	177/293 - (60%)	Gaps:	26/293 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  1045 AILR-----RPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKST----KLDVAVKTCRMTLPD 1100
            |:|:     .|.|..|.::          ||.|.||:|||..||::    ::.||:||.:....:
Mouse   601 AVLKFTTEIHPSCVARQKV----------IGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTE 655

  Fly  1101 EQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGM 1165
            :|:..||.|..|:.|:.|.||::|.|:..:.:|:||:.|.:..|:|..:||:.....:..|.:||
Mouse   656 KQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGM 720

  Fly  1166 CRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-----EEEEYIVSDGMKQIPVK 1225
            .|..|:||:||.:.|.:||||||||.||:.....|:||||:||     .|..|..|.|  :||::
Mouse   721 LRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGG--KIPIR 783

  Fly  1226 WTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMY 1290
            ||||||:::.|:||..|||||||:|||:.:.|:.||..::|....:.|:.|:|:|||...|..:|
Mouse   784 WTAPEAISYRKFTSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIY 848

  Fly  1291 RLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            :||:|||..:...||.|.:|.:::|.||...|:
Mouse   849 QLMMQCWQQERSRRPKFADIVSILDKLIRAPDS 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	105/256 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	106/256 (41%)
Epha2	NP_034269.2	Mediates interaction with CLDN4. /evidence=ECO:0000250	1..205
		EphR_LBD_A2	27..200	CDD:198448
		fn3	331..425	CDD:278470
		FN3	440..527	CDD:238020
		EphA2_TM	<579..609	CDD:291255	2/7 (29%)
		Mediates interaction with ARHGEF16. /evidence=ECO:0000250	607..907		113/287 (39%)
		PKc_like	608..876	CDD:304357	110/279 (39%)
		Pkinase_Tyr	618..872	CDD:285015	106/265 (40%)
		Negatively regulates interaction with ARHGEF16. /evidence=ECO:0000250	887..977
		SAM_EPH-A2	903..972	CDD:188942
		SAM	903..969	CDD:197735
		PDZ-binding. /evidence=ECO:0000255	975..977
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910