DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and PXDNL

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_653252.4	Gene:	PXDNL / 137902	HGNCID:	26359	Length:	1463	Species:	Homo sapiens

Alignment Length:	895	Identity:	166/895 - (18%)
Similarity:	266/895 - (29%)	Gaps:	343/895 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   576 NNNHI-------YADLE--------------LDKKKDTSPSPECKG--------------EQIQP 605
            |||||       :..||              |||:       ..||              |.:||
Human    82 NNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQ-------TFKGLISLEHLYIHFNQLEMLQP 139

  Fly   606 -------KKEQIRIEINQTA--PQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIES----- 656
                   :.|::.:..|:.:  |..|    ...:|.|.|:   ||        |.||:..
Human   140 ETFGDLLRLERLFLHNNKLSKIPAGS----FSNLDSLKRL---RL--------DSNALVCDCDLM 189

  Fly   657 ---------AEENHIQTRKLAKDPDSQTKRSSSSSS----ECRSSKDTSHSKKRSLSFSQKSISN 708
                     |:..|.|.....:.|.....|:.:|.:    .|:|.:         ::|..:.:..
Human   190 WLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPR---------ITFEPQDVEV 245

  Fly   709 IFSNLKEFS-------KSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSS------- 759
            ...|...|:       |..::.:..||.|:.|.|.:     .:....|:....|:..|
Human   246 PSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTR-----LNVFDDGTLMIRNTRESDQGVYQC 305

  Fly   760 -SSNNNNNNKNTSSNSNHS---ASQSTIITSTITTTITTTTTT-------------TPSKENSRL 807
             :.|:....|..|:...:|   |..|.:|....|..:..|:||             |.:::|.
Human   306 MARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNG-- 368

  Fly   808 KFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRR----IHPSKS--VFDFAKEFEVEQ 866
                    .:....|:...|..|..|        ..|:|..    .|.:.|  ....|....|:.
Human   369 --------LELDGSRHVATSSGLYLQ--------NITQRDHGRFTCHANNSHGTVQAAANIIVQA 417

  Fly   867 P------------AGSAADEQFC----NCPP-------AGQKPVKPSVQISGHKDHPFESSSGEL 908
            |            ....|.|..|    |.||       .||.||:....:         .|||.|
Human   418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV---------LSSGTL 473

  Fly   909 DENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLA---ASISLSTNRPLYEEEWFHGVLPRE-E 969
              ..||...:|:.:.:            |..|.||.   .|:.|:             |.|:. .
Human   474 --RIDRAAQHDQGQYE------------CQAVSSLGVKKVSVQLT-------------VKPKALA 511

  Fly   970 VVRLLNNDGDFLVRETIR-----NEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELI 1029
            |...|..|....|.:.|.     ..|.|.:::  ||...   ||.|..|.|..:.....:|
Human   512 VFTQLPQDTSVEVGKNINISCHAQGEPQPIIT--WNKEG---VQITESGKFHVDDEGTLTI---- 567

  Fly  1030 MHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRG-NFGDVYKAKLKSTKLDVAVKT 1093
               |.:..|...:...     |.|..:.|:..::.|.....:| ..||.:   ::|:.|| ||:.
Human   568 ---YDAGFPDQGRYEC-----VARNSFGLAVTNMFLTVTAIQGRQAGDDF---VESSILD-AVQR 620

  Fly  1094 CRMTLPDEQKRKFLQE----GRILKQYDHPNIVKLIGIC----VQKQPIMIVMELV-------LG 1143
            ....:...::..|.|:    ..:|.|:.:|....::.:.    :.:..:.::.|.|       |.
Human   621 VDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTVDLE 685

  Fly  1144 GSLLTY----------LRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHS 1198
            |....|          |..|.:|.|.|:.:..|           |..|.|
Human   686 GKEFRYNDLVSPRSLSLIANLSGCTARRPLPNC-----------SNRCFH--------------- 724

  Fly  1199 VKISDFGMSREEEEYIVSDGM---KQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTP 1260
                        .:|...||.   .|.|. |.|  ||.           ::..|:...:..|...
Human   725 ------------AKYRAHDGTCNNLQQPT-WGA--ALT-----------AFARLLQPAYRDGIRA 763

  Fly  1261 YSGMTNSRARERIDTGYRMPTPKS-------------TPEEMYRLMLQCW 1297
            ..|:       .:..|.|.|.|..             ||:..|..||..|
Human   764 PRGL-------GLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHW 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/91 (20%)
		TyrKc	1063..1311	CDD:197581	50/277 (18%)
		PTKc_Fes_like	1067..1315	CDD:270637	49/273 (18%)
PXDNL	NP_653252.4	LRR 1	51..72
		leucine-rich repeat	52..85	CDD:275378	2/2 (100%)
		LRR_8	53..134	CDD:316378	12/58 (21%)
		LRR 2	75..96		5/13 (38%)
		leucine-rich repeat	86..123	CDD:275378	8/43 (19%)
		LRR 3	99..120		3/27 (11%)
		LRR_8	123..182	CDD:316378	14/73 (19%)
		LRR 4	123..144		3/20 (15%)
		leucine-rich repeat	124..147	CDD:275378	3/22 (14%)
		LRR 5	147..168		4/24 (17%)
		leucine-rich repeat	148..171	CDD:275378	4/26 (15%)
		leucine-rich repeat	172..184	CDD:275378	7/22 (32%)
		LRRCT	180..232	CDD:214507	8/51 (16%)
		Ig_3	234..309	CDD:316449	12/88 (14%)
		Ig_3	329..402	CDD:316449	15/90 (17%)
		Ig	432..505	CDD:325142	23/108 (21%)
		Ig	528..596	CDD:325142	16/84 (19%)
		peroxidasin_like	851..1286	CDD:188658
		VWC	1400..1450	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910