DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Egfr

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_997538.1	Gene:	Egfr / 13649	MGIID:	95294	Length:	1210	Species:	Mus musculus

Alignment Length:	914	Identity:	192/914 - (21%)
Similarity:	323/914 - (35%)	Gaps:	280/914 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 NHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDE-------EPVVLASPAPLT-- 565
            :||.|..:.......:.|...|.|      |.:.|.:....:||       .|::|.:|....
Mouse   220 SHRCRGRSPSDCCHNQCAAGCTGP------RESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMD 278

  Fly   566 -------QLTAAVLTNTNNNHI--------------YADLELD-----KKKDTSPSPECKGEQIQ 604
                   ...|..:.....|::              |.::|.|     ||.|......|.|..|.
Mouse   279 VNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGIG 343

  Fly   605 PKKEQIRIEINQTAPQN-------SIDAHLDRI----DELNRV--LDDRLKRTLQPSDDVNAIES 656
            ..|:  .:.||.|..::       |.|.|:..:    |...|.  ||.|
Mouse   344 EFKD--TLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPR---------------- 390

  Fly   657 AEENHIQTRKLAKD----------PDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNI-F 710
                .::..|..|:          ||:.|...:..:.|....:...|. :.||:....:|::: .
Mouse   391 ----ELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHG-QFSLAVVGLNITSLGL 450

  Fly   711 SNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSN 775
            .:|||.|...::..|..::                      |..|:.:........|:.|...:|
Mouse   451 RSLKEISDGDVIISGNRNL----------------------CYANTINWKKLFGTPNQKTKIMNN 493

  Fly   776 HSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPC 840
                                                 :.:|..||:.:...      .|..|:.|
Mouse   494 -------------------------------------RAEKDCKAVNHVCN------PLCSSEGC 515

  Fly   841 -----KQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHP 900
                 :.|...:.:...:..        ||:          ||.
Mouse   516 WGPEPRDCVSCQNVSRGREC--------VEK----------CNI--------------------- 541

  Fly   901 FESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVL 965
            .|....|..|||:                  .::.|..|:|. |.:|:.:...|....:..|.:
Mouse   542 LEGEPREFVENSE------------------CIQCHPECLPQ-AMNITCTGRGPDNCIQCAHYI- 586

  Fly   966 PREEVVRLLNNDGDFLVRET---IRNEESQIVL------SVCWNGHKHFIVQTTGEGNFRFE--- 1018
                       ||...|:..   |..|.:.:|.      :||...|.:......|.|....|
Mouse   587 -----------DGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWP 640

  Fly  1019 -GPPFASIQELIMHQYHSELPVTVKSGAIL-RRPVCRERW------------------------- 1056
             ||...||...|:......:.|.:..|..: ||.:.|:|.
Mouse   641 SGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAH 705

  Fly  1057 --ELSNDDVVLLERIGRGNFGDVYKA----KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQ 1115
              .|...:...::.:|.|.||.|||.    :.:..|:.||:|..|.....:..::.|.|..::..
Mouse   706 LRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMAS 770

  Fly  1116 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKN 1180
            .|:|::.:|:|||: ...:.::.:|:..|.||.|:|::.:.:.::..:..|...|.||.|||.:.
Mouse   771 VDNPHVCRLLGICL-TSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRR 834

  Fly  1181 CIHRDLAARNCLVDLEHSVKISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLC 1241
            .:||||||||.||.....|||:|||:::    ||:||....|  ::|:||.|.|::....||...
Mouse   835 LVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGG--KVPIKWMALESILHRIYTHQS 897

  Fly  1242 DVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPH 1306
            ||||||:.:||:.:.|..||.|:..|.....::.|.|:|.|.....::|.:|::||..||:|||.
Mouse   898 DVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK 962

  Fly  1307 FDEI 1310
            |.|:
Mouse   963 FREL 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	19/98 (19%)
		TyrKc	1063..1311	CDD:197581	89/256 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	89/252 (35%)
Egfr	NP_997538.1	Recep_L_domain	57..168	CDD:279382
		Approximate	75..300		15/85 (18%)
		Furin-like	184..335	CDD:279142	21/120 (18%)
		FU	231..274	CDD:238021	10/48 (21%)
		Recep_L_domain	362..481	CDD:279382	25/161 (16%)
		Approximate	390..600		47/365 (13%)
		GF_recep_IV	505..636	CDD:291509	31/206 (15%)
		FU	506..559	CDD:238021	13/115 (11%)
		FU	552..598	CDD:214589	12/76 (16%)
		TM_ErbB1	634..679	CDD:213054	11/44 (25%)
		Important for dimerization, phosphorylation and activation. /evidence=ECO:0000250	690..706		0/15 (0%)
		PTKc_EGFR	706..1018	CDD:270683	90/264 (34%)
		TyrKc	715..970	CDD:197581	89/255 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1113..1137
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910