DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and M176.9

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001305207.1	Gene:	M176.9 / 13186458	WormBaseID:	WBGene00014813	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	451	Identity:	140/451 - (31%)
Similarity:	223/451 - (49%)	Gaps:	39/451 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   881 PAGQKPVKPSVQISGHKDHPFESSSGELD-ENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLA 944
            |....||..|     .:|....|..|..| |..:..:...|:.....|......|..|......:
Worm    43 PTTDGPVAGS-----RRDKLERSKRGTRDRERPEATLQPTEKSARGKSSRRKKKKPQCTAPEEKS 102

  Fly   945 ASISLSTNRPLYEE-----EWFHGVLPREEVVRLLNNDGDFLVR--ETIRNEES---QIVLSVCW 999
            ...|.....|:.|:     :::||.||||::...|:|.||:|:|  |.:..|..   :|:||: .
Worm   103 LMTSDREYFPVLEKTLRGFKFYHGFLPREDLQATLHNPGDYLIRVSEVVEGESKVVREIILSL-M 166

  Fly  1000 NGHK---------HFIVQTTGEGNFRFEGP-PFASIQELIMHQYHSELPVTVKSGAI-LRRPVCR 1053
            .||.         |.:|.......|..|.. |||::.:||  .|:::......||.. |:.|:.:
Worm   167 TGHMEGKQKEKRIHNVVIKRVSNKFFCEAARPFATVADLI--NYYTKHTGHCSSGNFQLKHPILQ 229

  Fly  1054 ERWELSNDDVVLLERIGRGNFGDVYKAKLK---STKLDVAVKTCRMT--LPDEQKRKFLQEGRIL 1113
            :.||..:.||.:.:.:|.|.||.|...:|:   .:..:||:|..:.:  |...:.::.:.|.|.:
Worm   230 QTWEFMHSDVTVGDVLGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMKIKEMMNEARFI 294

  Fly  1114 KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLES 1178
            :.::|.|:|:|.|:...:||:.|::|||.||||..|: |.:..:....::..|..||.|:.||..
Worm   295 RNFNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDYM-KQTKSVPLADRINFCLGAAKGLAYLHQ 358

  Fly  1179 KNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDV 1243
            .||||||:||||||:. |:.|||:|||:||....|......| ||:||.|||.|....::...||
Worm   359 NNCIHRDIAARNCLLH-ENEVKITDFGLSRAGPSYTTKTSCK-IPIKWLAPETLATLSFSYATDV 421

  Fly  1244 WSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESR 1304
            :|:|:..:|:|..|..|:.|::|:..:..|......|.|..||:|:...|..|...: |||
Worm   422 YSWGVTCYEVFVDGAEPFEGVSNATIKADIMANNFYPMPSMTPDEVKEYMSSCIFVE-ESR 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	31/105 (30%)
		TyrKc	1063..1311	CDD:197581	88/247 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	87/243 (36%)
M176.9	NP_001305207.1	SH2_Fps_family	116..212	CDD:198224	29/98 (30%)
		TyrKc	239..484	CDD:197581	88/247 (36%)
		PTKc	243..493	CDD:270623	87/243 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910