DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and AgaP_AGAP011648

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_320863.4	Gene:	AgaP_AGAP011648 / 1280989	VectorBaseID:	AGAP011648	Length:	706	Species:	Anopheles gambiae

Alignment Length:	804	Identity:	182/804 - (22%)
Similarity:	287/804 - (35%)	Gaps:	291/804 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 TNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRV--- 636
            |:.|.:|.::   ..|:.:...:.:|.|..|..:.||    |..|..   .:|..|....::
Mosquito   106 TSKNEVYVNI---LSKNATGLYKSRGSQFTPSIDNIR----QILPPG---INLPGISSRPQIPLP 160

  Fly   637 -LDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKR------SSSSSSECRSSKDTSHS 694
             |..:..|. .|:.....:||||     .......|..|||.      .:.::|....|..|:|.
Mosquito   161 PLPSQFTRK-PPTVPGPGLESAE-----ATPTPPPPSKQTKTYPDRPIGTGNASTMVDSSPTTHP 219

  Fly   695 KKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSS 759
            .:.|          :::..|.....|::.....|                        ||.:.:|
Mosquito   220 VEPS----------VYNGTKLSPIPPVINTTAPH------------------------PTIAGAS 250

  Fly   760 SSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTT---TTPSKENSRLKFKVPKIQKKSKAI 821
            |:                   .|.....:..||||.|.   ..|.:|.:.:|..:|.|  .|.||
Mosquito   251 ST-------------------PTTPKLPLQPTITTGTVPIHAHPHEETNTVKILLPVI--ISVAI 294

  Fly   822 RNT---------FRSKL--LNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQ 875
            ...         ||..|  |:..||:.....:..|..:.:.|.::...|
Mosquito   295 IFVTAGLIAICFFRKYLCALSKTLKKKNKIDKAKKSNQSNGSSNITSTA---------------- 343

  Fly   876 FCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCV 940
                                                           |||.:
Mosquito   344 -----------------------------------------------EDSRN------------- 348

  Fly   941 PSLAASISLS--------TNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSV 997
                 ||.||        :||  |...|                     .|:|
Mosquito   349 -----SIGLSHWTGPMAFSNR--YTSPW---------------------ERDT------------ 373

  Fly   998 CWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDD 1062
              |||.....|.:.|.|                             |:|:     ::|||.....
Mosquito   374 --NGHLQATSQLSEESN-----------------------------GSIV-----KDRWEFPRHR 402

  Fly  1063 VVLLERIGRGNFGDVYKAKLKSTKLD-------VAVKTCRMTLPDEQKRKFLQEGRILKQYD-HP 1119
            :.:...:|.|.||.|::.  ::|.:|       .||||.:....:.::...|.|.::||..: |.
Mosquito   403 LKVFNILGEGAFGQVWRC--EATDIDGHEGVSVTAVKTLKENASEAERNDLLSELQVLKSLEPHI 465

  Fly  1120 NIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK--------NSNG----LTTRQQMGMCRDAAAG 1172
            |:|:|:|.|.:|.||.:::|.|..|.|.|:||.        |::|    ||:..........|.|
Mosquito   466 NVVRLLGCCTEKDPIFVILEYVNMGKLQTFLRNSRVEKHYGNTHGKSKILTSGDLTSFMYQVARG 530

  Fly  1173 MRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIV--------SDGMKQIPVKWTAP 1229
            |.:|.|:..|||||||||.|:..:|:.|::|||.:|:    ||        |:|  ::|::|.|.
Mosquito   531 MDFLTSRGIIHRDLAARNILITDDHTCKVADFGFARD----IVTSKVYERKSEG--RLPIRWMAT 589

  Fly  1230 EALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLML 1294
            |:|....:|...|:||:|||||||.:.|.|||.|:..:....::..|||:..|:....|:|.:|.
Mosquito   590 ESLYDNIFTVKSDIWSFGILMWEIVTLGSTPYPGIAAADVMRKVRDGYRLEKPEHCRRELYNIMF 654

  Fly  1295 QCWAADAESRPHFDEIYNVVDALI 1318
            .|||||...||.|.|:..::|.|:
Mosquito   655 YCWAADPNERPGFPEVVEMLDRLL 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	11/85 (13%)
		TyrKc	1063..1311	CDD:197581	97/275 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/275 (35%)
AgaP_AGAP011648	XP_320863.4	Cadherin_repeat	32..119	CDD:206637	3/15 (20%)
		PTKc	407..675	CDD:270623	97/275 (35%)
		STYKc	408..674	CDD:214568	97/273 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910